Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment--a prospective, controlled study.
Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment--a prospective, controlled study.
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动脉粥样硬化性脂质谱是早期类风湿关节炎患者的特征特征：早期治疗的作用 - 一项前瞻性，对照研究。
DOI：
10.1186/ar1952
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发表时间：
2006
影响因子：
4.9
通讯作者：
Drosos, Alexandros A.
中科院分区：
文献类型：
--
作者：
Georgiadis, Athanasios N.;Papavasiliou, Eleni C.;Lourida, Evangelia S.;Alamanos, Yannis;Kostara, Christina;D Tselepis, Alexandros;Drosos, Alexandros A.
我们对早期类风湿关节炎(ERA)患者进行了免疫干预后的血脂谱和脂蛋白修饰的研究。符合美国风湿病学会(ACR)标准的58名ERA患者被纳入研究。这些患者的病程不到一年，并且事先没有接受过治疗。吸烟者或患有糖尿病、甲状腺功能减退症、肝脏或肾脏疾病、库欣综合征、肥胖、常见的血脂异常的患者以及那些接受影响脂质代谢的药物的患者被排除在研究之外。63名健康志愿者(对照组)也包括在内。患者接受甲氨蝶呤和泼尼松治疗。所有患者的血脂谱、28关节指数评分(DAS-28)的疾病活动性以及ACR的50%反应标准被确定。发病时DAS-28平均为5.8±0.9。经过一年的治疗，53例(91.3%)患者达到了ACR20%的疗效标准，而45例(77.6%)患者达到了ACR50%的标准。此外，DAS-28、C反应蛋白(CRP)和血沉(ESR)也明显下降。ERA患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和甘油三酯(TG)水平明显高于对照组，而高密度脂蛋白胆固醇(HDLC)水平显著低于对照组。因此，与对照组相比，ERA患者的TC/HDLc和LDL-C/HDLc的致动脉粥样硬化比率显著升高。治疗后TC/HDLc和LDLc/HDLc的致动脉粥样硬化比率明显降低，这主要是由于血清HDLc水平升高所致。这些改变与实验室改变呈负相关，尤其是与CRP和ESR呈负相关。总而言之，ERA患者的特点是具有致动脉粥样硬化的血脂谱，治疗后这种情况有所改善。因此，早期控制疾病活动的免疫干预可能会降低ERA患者动脉粥样硬化过程和心血管事件的风险。
We investigated lipid profiles and lipoprotein modification after immuno-intervention in patients with early rheumatoid arthritis (ERA). Fifty-eight patients with ERA who met the American College of Rheumatology (ACR) criteria were included in the study. These patients had disease durations of less than one year and had not had prior treatment for it. Smokers or patients suffering from diabetes mellitus, hypothyroidism, liver or kidney disease, Cushing's syndrome, obesity, familiar dyslipidemia and those receiving medications affecting lipid metabolism were excluded from the study. Sixty-three healthy volunteers (controls) were also included. Patients were treated with methotrexate and prednisone. Lipid profiles, disease activity for the 28 joint indices score (DAS-28) as well as ACR 50% response criteria were determined for all patients. The mean DAS-28 at disease onset was 5.8 ± 0.9. After a year of therapy, 53 (91.3%) patients achieved the ACR 20% response criteria, while 45 (77.6%) attained the ACR 50% criteria. In addition, a significant decrease in the DAS-28, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were observed. ERA patients exhibited higher serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides, whereas their serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower compared to controls. As a consequence, the atherogenic ratio of TC/HDL-C as well as that of LDL-C/HDL-C was significantly higher in ERA patients compared to controls. After treatment, a significant reduction of the atherogenic ratio of TC/HDL-C as well as that of LDL-C/HDL-C was observed, a phenomenon primarily due to the increase of serum HDL-C levels. These changes were inversely correlated with laboratory changes, especially CRP and ESR. In conclusion, ERA patients are characterized by an atherogenic lipid profile, which improves after therapy. Thus, early immuno-intervention to control disease activity may reduce the risk of the atherosclerotic process and cardiovascular events in ERA patients.
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类风湿关节炎与骨关节炎的心血管风险：急性期反应相关的胰岛素敏感性降低和高密度脂蛋白胆固醇以及类风湿关节炎中代谢综合征特征的聚类。
DOI：
10.1186/ar428
发表时间：
2002
期刊：
ARTHRITIS RESEARCH
影响因子：
--
作者：
Dessein, PH;Stanwix, AE;Joffe, BI
通讯作者：
Joffe, BI
影响因子：
37.8
作者：
Gotto, AM
通讯作者：
Gotto, AM
影响因子：
4.8
作者：
KANNEL, WB;NEATON, JD;KJELSBERG, MO
通讯作者：
KJELSBERG, MO
影响因子：
--
作者：
Gabriel, SE;Crowson, CS;Matteson, EL
通讯作者：
Matteson, EL
影响因子：
--
作者：
Barter, PJ
通讯作者：
Barter, PJ