Recent incidence trend of elderly patients with glioblastoma in the United States, 2000-2017.
Recent incidence trend of elderly patients with glioblastoma in the United States, 2000-2017.
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DOI：
10.1186/s12885-020-07778-1
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发表时间：
2021-01-12
期刊：
影响因子：
3.8
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Chen B;Chen C;Zhang Y;Xu J
胶质母细胞瘤的发病率随着年龄的增长而显著增加。随着人口的增长和老龄化，缺乏对美国近期胶质母细胞瘤发病率趋势的综合分析。本研究旨在深入描述胶质母细胞瘤发病率趋势的模式，并研究年龄-时期-队列对老年患者胶质母细胞瘤发病率趋势的影响。发病率经年龄调整，每10万人报告。我们使用Joinpoint回归程序计算了发病率的年变化百分比（APC），并对2000年至2017年期间报告的老年胶质母细胞瘤进行了年龄-时期队列分析，并对监测流行病学和最终结果（SEER） 18注册数据库进行了分析。2000年至2017年，老年胶质母细胞瘤患者的总发病率为13.16 / 10万（95% CI, 12.99-13.32）。非西班牙裔白人占多数（20406,83.6%）。男性发病率约为女性的1.62倍。所有老年患者的发病率趋势保持稳定，且无显著上升趋势（APC 0.3, 95% CI, - 0.1 ~ 0.7, p = 0.111）。有显著增加发病率趋势非西班牙裔白人(APC 0.6, 95%可信区间,0.2 - 1.1,p = 0.013),幕上的位置(APC 0.7, 95%可信区间,0.2 - 1.3,p = 0.016),肿瘤大小< 4厘米(APC 2.5, 95%可信区间,1.4 - 3.6,p < 0.001),显著减少趋势重叠/号位置(APC -0.9, 95%可信区间,1.6−−0.2,p = 0.012),和未知的肿瘤大小(APC -4.9, 95%可信区间,6.6−−3.3,p < 0.001)。年龄-时期-队列分析显示年龄对发病率趋势的影响（p< 0.001， Wald检验），而未显示胶质母细胞瘤发病率趋势的时期和队列效应（p = 0.063和p =0.536， Wald检验）。2000年至2017年，老年人群胶质母细胞瘤的总体发病率保持稳定。在胶质母细胞瘤发病率的趋势中，时期和队列效应不明显。未来以人群为基础的研究，通过特定的分子亚群来探索胶质母细胞瘤发病率趋势的差异，有必要进一步了解胶质母细胞瘤的病因。
The incidence of glioblastoma increases significantly with age. With the growing and aging population, there is a lack of comprehensive analysis of recent glioblastoma incidence trend in the United States. This study aims to provide in-depth description of the patterns of incidence trends and to examine the age-period-cohort effects to the trends of glioblastoma specific to elderly patients. The incidence rates were age-adjusted and reported per 100,000 population. We calculated the annual percent change (APC) in incidence using the Joinpoint Regression Program and conducted an age-period-cohort analysis of elderly glioblastoma reported between 2000 and 2017 to the Surveillance Epidemiology and End Results (SEER) 18 registry database. The overall incidence rate of elderly patients with glioblastoma was 13.16 per 100,000 (95% CI, 12.99–13.32) from 2000 to 2017. Non-Hispanic whites (20,406, 83.6%) made up the majority. The incidence rate of male was about 1.62 times that of female. The trend of incidence remained stable and there was a non-significant increasing tendency for all elderly patients (APC 0.3, 95% CI, − 0.1 to 0.7, p = 0.111). There was a significantly increasing incidence trend for non-Hispanic white (APC 0.6, 95% CI, 0.2 to 1.1, p = 0.013), supratentorial location (APC 0.7, 95% CI, 0.2 to 1.3, p = 0.016), tumor size < 4 cm (APC 2.5, 95% CI, 1.4 to 3.6, p < 0.001), and a significantly decreasing trend for overlapping/NOS location (APC -0.9, 95% CI, − 1.6 to − 0.2, p = 0.012), and unknown tumor size (APC -4.9, 95% CI, − 6.6 to − 3.3, p < 0.001). The age-period-cohort analysis showed the effect of age on incidence trends (p< 0.001, Wald test), while did not indicate the period and cohort effects of the incidence trends of glioblastoma (p = 0.063 and p =0.536, respectively, Wald test). The overall incidence of glioblastoma in the elderly population remained stable between 2000 and 2017. Period and cohort effects were not evident in the trend of glioblastoma incidence. Future population-based studies exploring the difference in the trend of glioblastoma incidence by specific molecular subgroups are warranted to further our understanding of the etiology of glioblastoma.
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DOI：
10.1016/s0140-6736(18)31694-5
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Foreman KJ;Marquez N;Dolgert A;Fukutaki K;Fullman N;McGaughey M;Pletcher MA;Smith AE;Tang K;Yuan CW;Brown JC;Friedman J;He J;Heuton KR;Holmberg M;Patel DJ;Reidy P;Carter A;Cercy K;Chapin A;Douwes-Schultz D;Frank T;Goettsch F;Liu PY;Nandakumar V;Reitsma MB;Reuter V;Sadat N;Sorensen RJD;Srinivasan V;Updike RL;York H;Lopez AD;Lozano R;Lim SS;Mokdad AH;Vollset SE;Murray CJL
通讯作者：
Murray CJL
影响因子：
5.4
作者：
Keyes, Katherine M.;Utz, Rebecca L.;Robinson, Whitney;Li, Guohua
通讯作者：
Li, Guohua
影响因子：
50.3
作者：
Phillips, HS;Kharbanda, S;Aldape, K
通讯作者：
Aldape, K
DOI：
10.1016/j.pathophys.2012.11.001
发表时间：
2013-04-01
期刊：
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子：
--
作者：
Hardell, Lennart;Carlberg, Michael;Hansson Mild, Kjell
通讯作者：
Hansson Mild, Kjell
DOI：
10.1136/bmj.e1147
发表时间：
2012-03-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Little MP;Rajaraman P;Curtis RE;Devesa SS;Inskip PD;Check DP;Linet MS
通讯作者：
Linet MS