Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States.
Mobile phone use and glioma risk: comparison of epidemiological study results with incidence trends in the United States.
复制标题
DOI：
10.1136/bmj.e1147
复制
发表时间：
2012-03-08
期刊：
影响因子：
--
通讯作者：
Linet MS
中科院分区：
文献类型：
--
作者：
Little MP;Rajaraman P;Curtis RE;Devesa SS;Inskip PD;Check DP;Linet MS
目的鉴于移动的手机暴露被国际癌症研究机构（IARC）列为可能的人类致癌物，我们确定了最近的两个报告的胶质瘤风险（形成IARC的分类的基础）与观察到的发病率趋势在美国的兼容性。设计：1997-2008年胶质瘤发病率的观察率与预测率的比较。我们通过结合2010年Interphone研究和2011年Hardell及其同事在瑞典进行的一项研究中报告的相对风险来估计预计发生率，并根据年龄、登记和性别、移动的电话使用数据和各种潜伏期进行了调整。 设定1992-2008年美国人群神经胶质瘤发病率数据，来自监测、流行病学和最终结果（SEER）项目的12个登记中心（亚特兰大、底特律、洛杉矶、旧金山弗朗西斯科、圣何塞-蒙特雷、西雅图、格鲁吉亚农村、康涅狄格州、夏威夷、爱荷华州、新墨西哥州和犹他州）。参与者数据来自24813名18岁或以上被诊断患有神经胶质瘤的非西班牙裔白色人。胶质瘤的年龄特异性发病率在1992-2008年保持基本不变（每年变化-0.02%，95%置信区间-0.28%至0.25%），这一时期与美国人口中移动的电话使用从接近0%大幅增加到几乎100%相吻合。如果使用手机与神经胶质瘤风险相关，我们预计神经胶质瘤发病率将高于观察结果，即使潜伏期为10年且相对风险较低（1.5）。根据瑞典研究中肿瘤潜伏期和手机使用累积小时数的胶质瘤相对风险，预测的发病率应比2008年观察到的发病率高至少40%。然而，基于对讲机研究中高度暴露人群的小比例预测的神经胶质瘤发病率可能与观察到的数据一致。如果我们使用非常规用户或低移动的手机用户作为基线类别，并且如果我们将相对风险限制为大于1，则结果仍然有效。结论使用移动的手机导致神经胶质瘤的风险升高，正如一项（瑞典）研究所报告的那样，该研究构成了IARC对移动的手机暴露的重新评估的基础，与美国人群数据中观察到的发病率趋势不一致，尽管美国数据可能与对讲机研究中的适度过度风险一致。
Objective In view of mobile phone exposure being classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC), we determined the compatibility of two recent reports of glioma risk (forming the basis of the IARC’s classification) with observed incidence trends in the United States. Design Comparison of observed rates with projected rates of glioma incidence for 1997-2008. We estimated projected rates by combining relative risks reported in the 2010 Interphone study and a 2011 Swedish study by Hardell and colleagues with rates adjusted for age, registry, and sex; data for mobile phone use; and various latency periods. Setting US population based data for glioma incidence in 1992-2008, from 12 registries in the Surveillance, Epidemiology, and End Results (SEER) programme (Atlanta, Detroit, Los Angeles, San Francisco, San Jose-Monterey, Seattle, rural Georgia, Connecticut, Hawaii, Iowa, New Mexico, and Utah). Participants Data for 24 813 non-Hispanic white people diagnosed with glioma at age 18 years or older. Results Age specific incidence rates of glioma remained generally constant in 1992-2008 (−0.02% change per year, 95% confidence interval −0.28% to 0.25%), a period coinciding with a substantial increase in mobile phone use from close to 0% to almost 100% of the US population. If phone use was associated with glioma risk, we expected glioma incidence rates to be higher than those observed, even with a latency period of 10 years and low relative risks (1.5). Based on relative risks of glioma by tumour latency and cumulative hours of phone use in the Swedish study, predicted rates should have been at least 40% higher than observed rates in 2008. However, predicted glioma rates based on the small proportion of highly exposed people in the Interphone study could be consistent with the observed data. Results remained valid if we used either non-regular users or low users of mobile phones as the baseline category, and if we constrained relative risks to be more than 1. Conclusions Raised risks of glioma with mobile phone use, as reported by one (Swedish) study forming the basis of the IARC’s re-evaluation of mobile phone exposure, are not consistent with observed incidence trends in US population data, although the US data could be consistent with the modest excess risks in the Interphone study.
登录
查看更多内容
影响因子：
19.7
作者：
Little, Mark P.;Wakeford, Richard;de Gonzalez, Amy Berrington
通讯作者：
de Gonzalez, Amy Berrington
影响因子：
7.7
作者：
Cardis, E.;Deltour, I.;Schoemaker, M. J.
通讯作者：
Schoemaker, M. J.
影响因子：
120.7
作者：
Muscat, JE;Malkin, MC;Wynder, EL
通讯作者：
Wynder, EL
影响因子：
5.4
作者：
Auvinen, A;Hietanen, M;Koskela, RS
通讯作者：
Koskela, RS
DOI：
10.1093/jnci/djp415
发表时间：
2009-12-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Deltour, Isabelle;Johansen, Christoffer;Schuz, Joachim
通讯作者：
Schuz, Joachim