Patterning principles of morphogen gradients.

Patterning principles of morphogen gradients.
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DOI:
10.1098/rsob.220224
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发表时间:
2022-10
期刊:
影响因子:
5.8
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

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后生动物胚胎从一个单细胞发育成三维结构的生物体,而基因相同的细胞群获得特殊的身份。发育中的胚胎细胞创造并准确地解释形态梯度,以确定它们的位置并做出特定的决定。在这里,我们首先介绍形态发生和位置信息概念的知识根源。重点是动物胚胎,然后我们提供了目前的理解形态梯度是如何建立和他们的跨度是如何控制的审查。最后,我们介绍了在开发过程中梯度如何在时间和空间中演变,以及它们如何编码信息以控制模式。总之,我们提供了形态因子梯度的模式原则列表,并回顾了最近在阐明形态因子提供的信息的定量方法方面的进展。
Metazoan embryos develop from a single cell into three-dimensional structured organisms while groups of genetically identical cells attain specialized identities. Cells of the developing embryo both create and accurately interpret morphogen gradients to determine their positions and make specific decisions in response. Here, we first cover intellectual roots of morphogen and positional information concepts. Focusing on animal embryos, we then provide a review of current understanding on how morphogen gradients are established and how their spans are controlled. Lastly, we cover how gradients evolve in time and space during development, and how they encode information to control patterning. In sum, we provide a list of patterning principles for morphogen gradients and review recent advances in quantitative methodologies elucidating information provided by morphogens.
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发表时间: 2004-10-15
期刊: CELL
影响因子: 64.5
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