Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.
Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.
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DOI：
10.1016/j.jacc.2021.06.050
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发表时间：
2021-09-21
影响因子：
24
通讯作者：
Jang, Ik-Kyung
中科院分区：
文献类型：
--
作者：
Aguirre, Aaron D.;Arbab-Zadeh, Armin;Soeda, Tsunenari;Fuster, Valentin;Jang, Ik-Kyung
关键词：
斑块破裂是急性冠状动脉综合征和心源性猝死的最常见原因。光学相干断层扫描（OCT）是一种微米级分辨率的血管内成像技术，在过去20年里，人们对易破裂斑块的特征和病理生物学进行了广泛研究。OCT研究已经确定了斑块易损的关键特征，并描述了薄帽纤维粥样瘤作为斑块破裂的主要前体的体内特征和空间分布。此外，OCT数据支持冠心病作为与炎症相关的全血管过程的不断发展的理解。在高动脉粥样硬化负荷的情况下，斑块破裂通常发生在冠状动脉的多个部位，斑块的进展和愈合是由全身危险因素调节的动态过程。这篇综述详细介绍了血管内OCT对斑块易损性和斑块破裂的生物学和临床意义的主要研究。二十年来，人们利用血管内光学相干断层扫描（OCT）广泛研究了易破裂斑块的特征和病理生物学。OCT提供了一个机会来研究薄帽纤维动脉粥样瘤作为斑块破裂的主要前体的体内特征和空间分布。此外，OCT数据支持冠心病作为一个与炎症相关的动态、全血管过程的不断发展的理解。这篇综述详细介绍了血管内OCT对斑块易损性和斑块破裂的生物学和临床意义的主要研究。
Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over two decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as major precursors to plaque rupture. In addition, OCT data supports the evolving understanding of coronary heart disease as a panvascular process associated with inflammation. In the setting of high atherosclerotic burden, plaque ruptures often occur at multiple sites in the coronary arteries and plaque progression and healing are dynamic processes modulated by systemic risk factors. This review details major investigations with intravascular OCT into the biology and clinical implications of plaque vulnerability and plaque rupture. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over two decades in humans using intravascular optical coherence tomography (OCT). OCT provided an opportunity to study the in vivo characteristics and spatial distribution of thin cap fibroatheromas as major precursors to plaque rupture. In addition, OCT data supports the evolving understanding of coronary heart disease as a dynamic, panvascular process associated with inflammation. This review details major investigations with intravascular OCT into the biology and clinical implications of plaque vulnerability and plaque rupture.
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影响因子：
39.3
作者：
Raffel, Owen Christopher;Merchant, Faisal M.;Jang, Ik-Kyung
通讯作者：
Jang, Ik-Kyung
影响因子：
2.8
作者：
Brezinski, ME;Tearney, GJ;Fujimoto, JG
通讯作者：
Fujimoto, JG
DOI：
10.1016/s0735-1097(02)02047-8
发表时间：
2002-09-04
影响因子：
24
作者：
Maehara, A;Mintz, GS;Weissman, NJ
通讯作者：
Weissman, NJ
影响因子：
14
作者：
Araki, Makoto;Soeda, Tsunenari;Jang, Ik-Kyung
通讯作者：
Jang, Ik-Kyung
影响因子：
37.8
作者：
MAZZONE, A;DESERVI, S;NOTARIO, A
通讯作者：
NOTARIO, A