Renin Release from Human Chorionic Trophoblasts in Vitro: The Role of Cyclic Amp and Protein Kinase C
Renin Release from Human Chorionic Trophoblasts in Vitro: The Role of Cyclic Amp and Protein Kinase C
复制标题
人绒毛膜滋养层体外肾素释放：环 Amp 和蛋白激酶 C 的作用
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
R. Poisner
中科院分区：
文献类型：
--
作者：
A. Poisner;P. Agrawal;R. Poisner
人绒毛膜滋养层含有肾素（Poisner 等，1981b）、HCG（Poisner 等，1983a）和黄体酮（Tonkowicz 和 Poisner，1985）。绒毛膜中的大部分肾素以肾素原的形式存在（Poisner 等，1981b）。初步研究表明，肾素释放依赖于外部钙，并且可以被阻止钙流入的药物抑制（Poisner 等，1983b；1984a，b）。这表明肾素释放可能是通过常见的钙依赖性胞吐作用途径介导的。二丁酰环 AMP 和增加环 AMP 的药物可增强这些细胞的孕酮分泌（Tonkowicz 和 Poisner，1985）。环磷酸腺苷也被认为是肾脏分泌肾素的介质（Fray，1980），但钙的作用存在争议（Chen 和 Poisner，1976；Park 等，1981；Hinko 等，1984）。许多细胞中的另一种分泌介质是二酰基甘油激活的蛋白激酶（C-激酶），它也被肿瘤启动子佛波酯激活（Castagna等人，1982）。本研究的目的是确定环 AMP 和蛋白激酶 C 是否也可以作为绒毛膜滋养层分泌肾素的介质。已有初步研究报告（Poisner，1984；Poisner 等人，1984b）。
Trophoblasts from human chorion laeve contain renin (Poisner et al., 1981b), HCG (Poisner et al., 1983a) and progesterone (Tonkowicz and Poisner, 1985). Most of the renin in the chorion is present in the form of prorenin (Poisner et al., 1981b). Preliminary work indicated that renin release is dependent on external calcium and can be inhibited by agents which block calcium influx (Poisner et al., 1983b; 1984a,b). This suggested that renin release may be mediated through the common calcium-dependent exocytosis pathway. Progesterone secretion from these cells is enhanced by dibutyryl cyclic AMP and agents which increase cyclic AMP (Tonkowicz and Poisner, 1985). Cyclic AMP has also been suggested as a mediator of renin secretion from the kidney (Fray, 1980), but the role of calcium is controversial (Chen and Poisner, 1976; Park et al., 1981; Hinko et al., 1984). Another mediator of secretion in a number of cells is the diacyl glycerol-activated protein kinase (C-kinase), which is also activated by the tumor promoter phorbol esters (Castagna et al., 1982). The present studies were carried out to determine if cyclic AMP and protein kinase C may also function as mediators of renin secretion from chorionic trophoblasts. Preliminary studies have been reported (Poisner, 1984; Poisner et al., 1984b).
钙控制肾素分泌：Ca2+流入作为抑制信号。
DOI：
10.1152/ajprenal.1981.240.1.f70
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
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作者：
Park,CS;Han,DS;Fray,JC
通讯作者：
Fray,JC
佛波酯在体外抑制卵巢和睾丸类固醇生成。
影响因子：
11.2
作者：
WelshJr,TH;Jones,PB;Hsueh,AJ
通讯作者：
Hsueh,AJ