Alterations in circadian rhythm phase shifting ability in rats following ethanol exposure during the third trimester brain growth spurt.
Alterations in circadian rhythm phase shifting ability in rats following ethanol exposure during the third trimester brain growth spurt.
复制标题
妊娠晚期大脑生长突增期间乙醇暴露后大鼠昼夜节律相移能力的变化。
DOI：
10.1111/j.1530-0277.2006.00105.x
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Thomas,JenniferD
中科院分区：
文献类型：
--
作者：
Sakata-Haga,Hiromi;Dominguez,HectorD;Sei,Hiroyoshi;Fukui,Yoshihiro;Riley,EdwardP;Thomas,JenniferD
背景：睡眠和喂养节律紊乱是产前酒精暴露的后果之一。在此之前，我们报道了大鼠在妊娠中期暴露于乙醇会对昼夜节律系统功能产生长期的损害。在本研究中，我们研究了乙醇暴露在孕晚期相当于大脑发育突增对生物钟系统发展的影响。方法：Sprague-Dawley雄性大鼠在出生后第4 ~ 9天（EtOH）通过人工饲养程序暴露于6.0 g/kg/d乙醇中。另设人工饲养胃造口对照组和正常饲养乳牛对照组。在10至12周龄时，在12小时/12小时光照/黑暗（LD）循环下连续测量车轮运行行为。之后，受试者被暴露于延迟6小时的LD周期中，并评估其适应新LD周期的能力。结果：延迟期前，三组小鼠活动起始时间和活动结束期差异无统计学意义。在LD周期延迟6小时后，与两个对照组相比，EtOH受试者适应新周期的速度较慢，这是通过活动开始和末期来测量的。在整个实验过程中，与两个对照组相比，EtOH受试者的活动水平往往更高。结论：这些数据表明，在妊娠晚期暴露于乙醇会破坏昼夜节律与光照同步的能力。昼夜节律调节的中断可能导致异常的行为节律，如睡眠和喂养模式的中断，如在产前暴露于乙醇的个体中所见。
Background:Disruptions in sleep and feeding rhythms are among the consequences of prenatal alcohol exposure. Previously, we reported that ethanol exposure during the second trimester equivalent in rats produces long‐lasting impairments in circadian system functioning. In the present study, we examined the effects of ethanol exposure during the third trimester equivalent brain growth spurt on the development of the circadian clock system.Methods:Sprague–Dawley male rat pups were exposed to 6.0 g/kg/d ethanol via an artificial rearing procedure on postnatal days (PD) 4 through 9 (EtOH). An artificially reared gastrostomized control group and a normally reared suckle control group were also included. At 10 to 12 weeks of age, wheel‐running behavior was measured continuously under a 12‐hour/12‐hour light/dark (LD) cycle. Thereafter, subjects were exposed to a 6‐hour phase delay of the LD cycle, and the ability to adjust to the new LD cycle was evaluated.Results:Before the phase delay, onset time of activity and acrophases of activity in all 3 groups were not significantly different from one another. After the 6‐hour LD cycle delay, EtOH subjects were slower to adapt to the new cycle compared with both control groups, as measured by both activity onset and acrophase. Throughout the experiment, activity levels of EtOH subjects tended to be higher compared to both controls.Conclusions:These data demonstrate that ethanol exposure during the third trimester disrupts the ability to synchronize circadian rhythm to light cues. Disruptions in circadian regulation may cause abnormal behavioral rhythmicity, such as disrupted sleep and feeding patterns, as seen in individuals prenatally exposed to ethanol.
登录
查看更多内容
仓鼠和大鼠视网膜下丘脑束的发育。
DOI：
10.1016/0165-3806(93)90205-o
发表时间：
1993
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Speh,JC;Moore,RY
通讯作者：
Moore,RY
产前接触酒精的儿童注意力缺陷。
DOI：
10.1111/j.1530-0277.1990.tb01223.x
发表时间：
1990
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
J. Nanson;M. Hiscock
通讯作者：
M. Hiscock
DOI：
10.1111/j.1530-0277.2002.tb02671.x
发表时间：
2002-08
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Jennifer D Thomas;S. Fleming;E. Riley
通讯作者：
Jennifer D Thomas;S. Fleming;E. Riley
早期接触可卡因对成人昼夜节律系统的光反应性的长期影响。
影响因子：
2.9
作者：
Strother,WN;Vorhees,CV;Lehman,MN
通讯作者：
Lehman,MN
DOI：
--
发表时间：
1994-12
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Y. H. Lee;K. Spuhler-Phillips;P. Randall;S. W. Leslie
通讯作者：
Y. H. Lee;K. Spuhler-Phillips;P. Randall;S. W. Leslie