Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare.
Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare.
复制标题
DOI：
10.1136/bmjnph-2020-000100
复制
发表时间：
2020
影响因子：
--
通讯作者：
Kohlmeier M
中科院分区：
文献类型：
--
作者：
McAuliffe S;Ray S;Fallon E;Bradfield J;Eden T;Kohlmeier M
现有的微量营养素缺乏症，即使只有一种微量营养素，也会损害免疫功能，增加对传染病的易感性。某些人口群体更有可能缺乏微量营养素，而某些疾病的病理和治疗方法也加剧了风险，这意味着这些群体往往会因传染病而增加发病率和死亡率。包括微量营养素在内的全面营养状况的优化可有效降低传染病的发病率。营养素缺乏症很少被发现，但在英国普遍存在，而且更广泛，特别是在易感染COVID-19的高危人群中。从业人员应意识到这一事实，并应将其作为COVID-19筛查过程的一个考虑因素，或者当筛查可能很困难或不切实际时，以确保按照最佳实践指南进行全面治疗。纠正已确定的微量营养素缺乏症，或在某些情况下假定的次优状态，有可能帮助支持免疫功能和减轻感染风险。COVID-19的影响和免疫反应与特征更为明确的严重急性呼吸道感染具有共同特征。纠正微量营养素缺乏症已被证明对几种传染病有效，并已被证明可促进有利的临床结果。营养素似乎在介导炎症反应中起关键作用，并且这种作用可以通过纠正缺陷来增强。在COVID-19大流行期间，许多风险最高的人群也是微量营养素缺乏和整体营养状况较差的风险最高的人群。纠正已确诊的COVID-19感染中的微量营养素缺乏可能有助于支持高风险人群对感染的免疫反应。有必要进一步研究，以建立最佳的公共卫生实践和临床干预方案。
Existing micronutrient deficiencies, even if only a single micronutrient, can impair immune function and increase susceptibility to infectious disease. Certain population groups are more likely to have micronutrient deficiencies, while certain disease pathologies and treatment practices also exacerbate risk, meaning these groups tend to suffer increased morbidity and mortality from infectious diseases. Optimisation of overall nutritional status, including micronutrients, can be effective in reducing incidence of infectious disease. Micronutrient deficiencies are rarely recognised but are prevalent in the UK, as well as much more widely, particularly in high-risk groups susceptible to COVID-19. Practitioners should be aware of this fact and should make it a consideration for the screening process in COVID-19, or when screening may be difficult or impractical, to ensure blanket treatment as per the best practice guidelines. Correction of established micronutrient deficiencies, or in some cases assumed suboptimal status, has the potential to help support immune function and mitigate risk of infection. The effects of and immune response to COVID-19 share common characteristics with more well-characterised severe acute respiratory infections. Correction of micronutrient deficiencies has proven effective in several infectious diseases and has been shown to promote favourable clinical outcomes. Micronutrients appear to play key roles in mediating the inflammatory response and such effects may be enhanced through correction of deficiencies. Many of those at highest risk during the COVID-19 pandemic are also populations at highest risk of micronutrient deficiencies and poorer overall nutrition. Correction of micronutrient deficiencies in established COVID-19 infection may contribute to supporting immune response to infection in those at highest risk. There is a need for further research to establish optimal public health practice and clinical intervention regimens.
登录
查看更多内容
DOI：
10.1016/j.ecl.2013.02.004
发表时间：
2013-06
影响因子：
4.5
作者：
Gallagher, J. Christopher
通讯作者：
Gallagher, J. Christopher
影响因子：
3.1
作者：
Chen, Honglei;Lu, Rong;Sun, Jun
通讯作者：
Sun, Jun
DOI：
10.1164/rccm.200711-1664st
发表时间：
2010-05-15
影响因子：
24.7
作者：
Brochard, Laurent;Abroug, Fekri;Polderman, Kees H.
通讯作者：
Polderman, Kees H.
影响因子：
7.1
作者：
Besecker, Beth Y.;Exline, Matthew C.;Knoell, Daren L.
通讯作者：
Knoell, Daren L.
影响因子：
120.7
作者：
Fowler, Alpha A., III;Truwit, Jonathon D.;Halquist, Matthew
通讯作者：
Halquist, Matthew