Genes and genomes: chromosome bands – flavours to savour

Genes and genomes: chromosome bands – flavours to savour
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基因和基因组:染色体带——品味

DOI:
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发表时间:
1993
期刊:
影响因子:
--
通讯作者:
W. Bickmore
W. Bickmore
中科院分区:
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文献类型:
--
作者:
J. Craig;W. Bickmore

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哺乳动物的染色体在结构和功能上是纵向不同的,这是各种染色体染色技术产生特定带型的基础。两种最常用的技术是G或Giemsa带状和R或反向带状。每种类型的染色条带的特征是基因密度、复制时间、碱基组成、重复序列的密度和染色质包装的变化。越来越明显的是,R带和G带是相辅相成的,它们代表着人类常染色体基因组的不同部分,其中R带包含绝大多数基因。与G带相比,R带的GC含量更高,Alu重复密度更高,在S期的复制更早。这些特性可能是相互依赖的,也可能是共同进化的。
The mammalian chromosome is longitudinally heterogeneous in structure and function and this is the basis for the specific banding patterns produced by various chromosome staining techniques. The two most frequently used techniques are G, or Giemsa banding and R, or reverse banding. Each type of stained band is characterised by variations in gene density, time of replication, base composition, density of repeat sequences, and chromatin packaging. It is increasingly apparent that R and G bands, which are complementary to each other, represent separate compartments of the euchromatic human genome, with R bands containing the vast majority of genes. R bands are also more GC-rich, contain a higher density of Alu repeats, and replicate earlier in S phase, than G bands. These properties may be interdependent and may have coevolved.
11 号染色体短臂上 WAGR 复合体周围的物理图。
DOI: 10.1016/0888-7543(89)90084-0
发表时间: 1989
期刊: Genomics
影响因子: 4.4
作者:
Gessler,M;Bruns,GA
通讯作者: Bruns,GA
人类21号染色体分析:物理图谱和细胞遗传学图谱的相关性;
DOI: 10.1002/j.1460-2075.1990.tb08076.x
发表时间: 1990
期刊: The EMBO journal
影响因子: --
作者:
Gardiner,K;Horisberger,M;Kraus,J;Tantravahi,U;Korenberg,J;Rao,V;Reddy,S;Patterson,D
通讯作者: Patterson,D