Prevalence and Determinants of Vitamin D Deficiency in 1825 Cape Town Primary Schoolchildren: A Cross-Sectional Study.
Prevalence and Determinants of Vitamin D Deficiency in 1825 Cape Town Primary Schoolchildren: A Cross-Sectional Study.
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DOI：
10.3390/nu14061263
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发表时间：
2022-03-16
期刊：
影响因子：
5.9
通讯作者：
Martineau AR
中科院分区：
文献类型：
--
作者：
Middelkoop K;Walker N;Stewart J;Delport C;Jolliffe DA;Nuttall J;Coussens AK;Naude CE;Tang JCY;Fraser WD;Wilkinson RJ;Bekker LG;Martineau AR
在南非开普敦，维生素D缺乏症(25-羟基维生素D[25(OH)D]<；50nmol/L)在成年人中很常见，但在这种情况下调查儿童维生素D状况的研究缺乏。我们进行了一项横断面研究，以确定开普敦1825名6-11岁学龄儿童维生素D缺乏症的患病率和决定因素。维生素D缺乏症患病率为7.6%(95%可信区间为6.5%~8.9%)。维生素D缺乏的决定因素包括抽样月份(7-9月与1-3月的调整后优势比(AOR)为10.69，95%可信区间为5.02至22.77；10-12月的调整优势比(AOR)为6.73，95%可信区间为2.82至16.08)、年龄较大(AOR为1.25，每增加一年，95%CI：1.01-1.53)和较高的体重指数(BMI；BMI-for-age Z-Score每单位增加的AOR为1.24，95%CI：1.03-1.49)。在370名参与者的子组中，测量了甲状旁腺激素(PTH)浓度；这些浓度与血清25(OH)D浓度呈负相关(p<；0.001)。然而，未发现甲状旁腺功能亢进症(PTH>；6.9pmol/L)与维生素D缺乏之间的联系(p=0.42)。总之，我们报告了季节是开普敦小学生维生素D状况的主要决定因素，维生素D缺乏症的患病率从1-3月的1.4%到7-9月的22.8%不等。
Vitamin D deficiency (25-hydroxyvitamin D[25(OH)D] <50 nmol/L) is common among adults in Cape Town, South Africa, but studies investigating vitamin D status of children in this setting are lacking. We conducted a cross-sectional study to determine the prevalence and determinants of vitamin D deficiency in 1825 Cape Town schoolchildren aged 6–11 years. Prevalence of vitamin D deficiency was 7.6% (95% Confidence Interval [CI] 6.5% to 8.9%). Determinants of vitamin D deficiency included month of sampling (adjusted odds ratio [aOR] for July–September vs. January–March 10.69, 95% CI 5.02 to 22.77; aOR for October–December vs. January–March 6.73, 95% CI 2.82 to 16.08), older age (aOR 1.25 per increasing year, 95% CI: 1.01–1.53) and higher body mass index (BMI; aOR 1.24 per unit increase in BMI-for-age Z-score, 95% CI: 1.03–1.49). In a subset of 370 participants in whom parathyroid hormone (PTH) concentrations were measured; these were inversely related to serum 25(OH)D concentrations (p < 0.001). However, no association between participants with hyperparathyroidism (PTH >6.9 pmol/L) and vitamin D deficiency was seen (p = 0.42). In conclusion, we report that season is the major determinant of vitamin D status among Cape Town primary schoolchildren, with prevalence of vitamin D deficiency ranging from 1.4% in January–March to 22.8% in July–September.
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DOI：
10.1016/s2213-2600(17)30306-5
发表时间：
2017-11
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Jolliffe DA;Greenberg L;Hooper RL;Griffiths CJ;Camargo CA Jr;Kerley CP;Jensen ME;Mauger D;Stelmach I;Urashima M;Martineau AR
通讯作者：
Martineau AR
影响因子：
3.7
作者：
Esposito S;Lelii M
通讯作者：
Lelii M
影响因子：
3.7
作者：
Wakayo, Tolassa;Belachew, Tefera;Whiting, Susan J.
通讯作者：
Whiting, Susan J.
影响因子：
8
作者：
El-Hajj Fuleihan, G;Nabulsi, M;Tannous, R
通讯作者：
Tannous, R
影响因子：
7.1
作者：
Ganmaa, Davaasambuu;Giovannucci, Edward;Willett, Walter C.
通讯作者：
Willett, Walter C.