Declining prevalence of probable depression among patients presenting for antiretroviral therapy in rural Uganda: the role of early treatment initiation.
Declining prevalence of probable depression among patients presenting for antiretroviral therapy in rural Uganda: the role of early treatment initiation.
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DOI：
10.1007/s10461-014-0785-0
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发表时间：
2015-01
影响因子：
4.4
通讯作者：
Tsai, Alexander C.
中科院分区：
文献类型：
--
作者：
Chan, Brian T.;Weiser, Sheri D.;Boum, Yap;Haberer, Jessica E.;Kembabazi, Annet;Hunt, Peter W.;Martin, Jeffrey N.;Mocello, A. Rain;Bangsberg, David R.;Tsai, Alexander C.
对于低收入和中等收入国家艾滋病毒感染者 (PLHIV) 开始抗逆转录病毒治疗 (ART) 时抑郁症的趋势知之甚少。我们使用来自乌干达农村地区未接受治疗的艾滋病病毒感染者队列的数据来估计开始接受抗逆转录病毒治疗时艾滋病病毒感染者抑郁症的长期趋势。我们拟合了线性回归模型，以抑郁症状严重程度作为结果变量，以队列进入年份（2005-2012）作为解释变量，调整社会人口统计学变量并评估身体健康评分、体重指数（BMI）和CD4计数作为抑郁症状严重程度长期趋势的潜在中介因素。进入年份与抑郁症状严重程度之间存在统计学上显着的负相关，表明在第一年之后的每一年研究招募中，开始 ART 时的平均抑郁症状严重程度评分相对下降 3.1%。在将基线社会人口特征纳入模型后，这一趋势在统计上仍然显着，并且似乎是由身体健康评分的改善驱动的，而不是 CD4 计数或 BMI。
Little is known about trends in depression at antiretroviral therapy (ART) initiation among people living with HIV (PLHIV) in low- and middle-income countries. We used data from an ongoing cohort of treatment-naïve PLHIV in rural Uganda to estimate secular trends in depression among PLHIV at ART initiation. We fitted linear regression models with depression symptom severity as the outcome variable and year of cohort entry (2005–2012) as the explanatory variable, adjusting for socio-demographic variables and assessing physical health score, body mass index (BMI), and CD4 count as potential mediators of a secular trend in depression symptom severity. There was a statistically significant negative association between year of entry and depression symptom severity, suggesting a 3.1% relative decline in the mean depression symptom severity score at ART initiation in each year of study recruitment after the first year. This trend remained statistically significant after inclusion of baseline socio-demographic characteristics to the model and appeared to be driven by improved physical health scores, but not CD4 count or BMI.
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DOI：
10.1080/09540120310001633994
发表时间：
2004-01-01
影响因子：
1.7
作者：
Mast, TC;Kigozi, G;Wu, AW
通讯作者：
Wu, AW
影响因子：
4.7
作者：
Olley, Benjamin O.;Seedat, Soraya;Stein, Dan J.
通讯作者：
Stein, Dan J.
影响因子：
3.5
作者：
Filmer, D;Pritchett, LH
通讯作者：
Pritchett, LH
影响因子：
4.4
作者：
Kaharuza, Frank M.;Bunnell, Rebecca;Mermin, Jonathan
通讯作者：
Mermin, Jonathan
影响因子：
12.7
作者：
Cook, JA;Grey, D;Hessol, NA
通讯作者：
Hessol, NA