Role of thymic stromal lymphopoietin in allergy and beyond.
Role of thymic stromal lymphopoietin in allergy and beyond.
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DOI：
10.1038/s41577-022-00735-y
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发表时间：
2023-01
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影响因子：
--
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胸腺基质淋巴生成素（TSLP）是一种多效性细胞因子，作用于多种细胞系，包括树突状细胞、T细胞、B细胞、中性粒细胞、肥大细胞、嗜酸性粒细胞和先天淋巴样细胞，影响它们的成熟、存活和募集。TSLP以其在促进2型免疫反应（如过敏性疾病）中的作用而闻名。2021年，一种靶向TSLP的单克隆抗体被批准用于治疗严重哮喘。然而，现在很清楚的是，TSLP在各种情况下还有许多其他重要的作用。事实上，TSLP的一些遗传变异与疾病的严重程度有关，TSLP的染色体改变在某些癌症中很常见，表明TSLP在疾病中的重要作用。本文综述了TSLP在变应性疾病、感染性疾病、炎症性疾病和癌症等疾病中调控组织环境的生物学研究进展。令人鼓舞的是，针对TSLP途径的治疗正在积极寻求用于几种疾病。细胞因子胸腺基质淋巴生成素（TSLP）除了过敏性疾病和辅助性T 2型免疫应答外，还具有多种功能。在这里，作者强调了TSLP通过作用于许多不同的细胞类型在感染性疾病、慢性炎症性疾病和癌症中的作用（有益或有害）。
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and recruitment. It is best known for its role in promoting type 2 immune responses such as in allergic diseases and, in 2021, a monoclonal antibody targeting TSLP was approved for the treatment of severe asthma. However, it is now clear that TSLP has many other important roles in a variety of settings. Indeed, several genetic variants for TSLP are linked to disease severity, and chromosomal alterations in TSLP are common in certain cancers, indicating important roles of TSLP in disease. In this Review, we discuss recent advances in TSLP biology, highlighting how it regulates the tissue environment not only in allergic disease but also in infectious diseases, inflammatory diseases and cancer. Encouragingly, therapies targeting the TSLP pathway are being actively pursued for several diseases. The cytokine thymic stromal lymphopoietin (TSLP) has pleiotropic functions beyond allergic diseases and T helper 2-type immune responses. Here, the authors highlight the roles of TSLP — beneficial or deleterious — in infectious disease, chronic inflammatory disease and cancer by acting on many different cell types.
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影响因子：
5.3
作者：
Calven, Jenny;Yudina, Yulyana;Uller, Lena
通讯作者：
Uller, Lena
DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Delespesse G
DOI：
10.1126/science.abd2893
发表时间：
2021-07-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Kambayashi T
影响因子：
4.6
作者：
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通讯作者：
Agner T
影响因子：
20.3
作者：
Chang, Yunchao;Min, Jaeki;Mullighan, Charles G.
通讯作者：
Mullighan, Charles G.