A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model.
A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model.
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DOI：
10.1007/s10554-010-9596-1
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发表时间：
2010-06
影响因子：
2.1
通讯作者：
Yeghiazarians, Yerem
中科院分区：
文献类型：
--
作者：
Koskenvuo, Juha W.;Mirsky, Rachel;Zhang, Yan;Angeli, Franca S.;Jahn, Sarah;Alastalo, Tero-Pekka;Schiller, Nelson B.;Boyle, Andrew J.;Chatterjee, Kanu;De Marco, Teresa;Yeghiazarians, Yerem
关键词：
肺动脉高压（PAH）是一种危及生命的疾病，其特征为肺动脉压（PAP）和总肺血管阻力（TPVR）进行性升高。成像技术的最新进展允许开发新的超声心动图参数来评估疾病进展。然而，没有报告将这些非侵入性参数的诊断性能相互比较以及与侵入性测量进行比较。因此，我们在大鼠模型中研究了超声心动图衍生的TPVR和PAP多普勒参数在筛选和测量PAH严重程度中的诊断率。在基线、野百合碱诱导PAH后21天和35天进行系列超声心动图和侵入性测量。最具挑战性的超声心动图TPVR测量与有创测量具有良好的相关性（r = 0.92，P < 0.001），但也发现更简单和新的TPVR参数是有用的，尽管由于缺乏足够的三尖瓣反流，只有29%的研究中无创TPVR测量是可行的。然而，超声心动图测量的PAP，肺动脉血流加速时间（PAAT）和减速（PAD），在所有动物中都是可测量的，并且与侵入性PAP相关（r =-0.74和r = 0.75，P < 0.001）。右室厚度和右室面积与有创PAP相关（r = 0.59和r = 0.64，P均< 0.001）。除了组织多普勒等容舒张时间外，有创和无创参数的观察者变异性较低。这些非侵入性参数可用于替代侵入性测量以检测成功的疾病诱导，并补充侵入性数据以评价大鼠模型中PAH的严重程度。
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by progressive elevation in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (TPVR). Recent advances in imaging techniques have allowed the development of new echocardiographic parameters to evaluate disease progression. However, there are no reports comparing the diagnostic performance of these non-invasive parameters to each other and to invasive measurements. Therefore, we investigated the diagnostic yield of echocardiographically derived TPVR and Doppler parameters of PAP in screening and measuring the severity of PAH in a rat model. Serial echocardiographic and invasive measurements were performed at baseline, 21 and 35 days after monocrotaline-induction of PAH. The most challenging echocardiographic derived TPVR measurement had good correlation with the invasive measurement (r = 0.92, P < 0.001) but also more simple and novel parameters of TPVR were found to be useful although the non-invasive TPVR measurement was feasible in only 29% of the studies due to lack of sufficient tricuspid valve regurgitation. However, echocardiographic measures of PAP, pulmonary artery flow acceleration time (PAAT) and deceleration (PAD), were measurable in all animals, and correlated with invasive PAP (r = −0.74 and r = 0.75, P < 0.001 for both). Right ventricular thickness and area correlated with invasive PAP (r = 0.59 and r = 0.64, P < 0.001 for both). Observer variability of the invasive and non-invasive parameters was low except in tissue-Doppler derived isovolumetric relaxation time. These non-invasive parameters may be used to replace invasive measurements in detecting successful disease induction and to complement invasive data in the evaluation of PAH severity in a rat model.
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影响因子：
2.8
作者：
MARTINDURAN, R;LARMAN, M;NISTAL, F
通讯作者：
NISTAL, F
DOI：
10.1152/ajpheart.00369.2006
发表时间：
2006-11-01
影响因子：
4.8
作者：
Hessel, Marleen H. M.;Steendijk, Paul;van der Laarse, Arnoud
通讯作者：
van der Laarse, Arnoud
影响因子：
9.6
作者：
Chemla, D;Castelain, V;Hervé, P
通讯作者：
Hervé, P
影响因子：
--
作者：
Brechot, Nicolas;Gambotti, Laetitia;Roudaut, Raymond
通讯作者：
Roudaut, Raymond
影响因子：
2.8
作者：
Abbas, AE;Fortuin, FD;Lester, SJ
通讯作者：
Lester, SJ