Nanoscale partitioning of paclitaxel in hybrid lipid-polymer membranes.
Nanoscale partitioning of paclitaxel in hybrid lipid-polymer membranes.
复制标题
DOI：
10.1039/c8an00838h
复制
发表时间：
2018-08-06
期刊：
影响因子：
--
通讯作者：
Centrone A
中科院分区：
文献类型：
--
作者：
Tuteja M ;Kang M ;Leal C ;Centrone A
紫杉醇是一种治疗再狭窄和多种癌症的强效药物。然而，它的临床应用取决于能否在阻碍药物结晶的同时在水悬浮液中实现适当的稳定药物浓度。要设计这样的制剂，必须了解紫杉醇在载体基质中的分配和结晶。脂质-聚合物杂化薄膜最近被证明可以容纳大量紫杉醇负载并抑制结晶。此外，与纯成分相比，这种杂化材料促进了药物的协同释放。在这里，我们利用成分敏感的光热诱导共振(PTIR)技术在纳米尺度上研究紫杉醇在杂化薄膜中的分配。PTIR数据显示，紫杉醇纳米晶体从只含脂类的薄膜中分离出来，但在仅含聚合物的薄膜中分散良好。值得注意的是，脂类-聚合物杂化膜显示紫杉醇在脂类-聚合物相界面的分配增强，但仍抑制结晶，从而为小药物输送系统的组成和微观结构工程铺平了道路。
Paclitaxel is a powerful drug against restenosis and many forms of cancer. However, its clinical application hinges on the ability to achieve suitable stabilized drug concentrations in an aqueous suspension while hindering drug crystallization. To engineer such formulations, it is imperative to understand paclitaxel’s partitioning and crystallization within the carrier matrix. Lipid-polymer hybrid films have been recently shown to accommodate large paclitaxel loads and suppress crystallization. Additionally, such hybrid materials promote synergistic drug release compared to the pure constituents. Here, we leverage the composition sensitive photo-thermal induced resonance (PTIR) technique to study paclitaxel partitioning within hybrid films at the nanoscale. PTIR data reveal that paclitaxel nano-crystals segregate from lipid-only films but are well dispersed in polymer-only films. Remarkably, lipid-polymer hybrid films show enhanced partitioning of paclitaxel at the lipid-polymer phase boundaries, but still stifle crystallization, thus paving the way towards compositional and microstructural engineering of small-drug delivery systems.
登录
查看更多内容
影响因子：
16.6
作者：
Khanikaev AB;Arju N;Fan Z;Purtseladze D;Lu F;Lee J;Sarriugarte P;Schnell M;Hillenbrand R;Belkin MA;Shvets G
通讯作者：
Shvets G
影响因子：
7.4
作者：
Katzenmeyer, Aaron M.;Holland, Glenn;Centrone, Andrea
通讯作者：
Centrone, Andrea
影响因子：
35
作者：
Lu, Feng;Jin, Mingzhou;Belkin, Mikhail A.
通讯作者：
Belkin, Mikhail A.
影响因子：
4.2
作者：
Barlow, Daniel E.;Biffinger, Justin C.;Russell, John N., Jr.
通讯作者：
Russell, John N., Jr.
DOI：
10.1146/annurev-anchem-071114-040435
发表时间：
2015-01-01
期刊：
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 8
影响因子：
--
作者：
Centrone, Andrea
通讯作者：
Centrone, Andrea