Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.
Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.
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DOI：
10.1093/cercor/bhab284
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发表时间：
2022-03-04
期刊：
影响因子：
--
通讯作者：
Scheinost D
中科院分区：
文献类型：
--
作者：
Rolison M;Lacadie C;Chawarska K;Spann M;Scheinost D
自闭症谱系障碍（ASD）的特征是功能网络的非典型连接偏侧化。然而，以前的研究没有直接调查，如果ASD和典型发展（TD）的同行之间的专业化差异存在于婴儿期，离开这些差异的发病时间相对未知。我们研究了ASD儿童和后来符合ASD诊断标准的婴儿的大脑半球连接不对称性。对733名ASD和TD同龄儿童以及71名ASD高风险（HR）或正常风险（NR）婴儿进行了分析，收集了1个月和9个月大的数据。将ASD儿童（n = 301）与TD儿童（n = 432）进行比较，发现有四个区域在连接性方面存在组间差异：后扣带皮层（PCC）、后上级颞回、纹外皮层和前额叶皮层。在1个月时，这些区域在ASD（n = 10）、HR-非ASD（n = 15）或NR（n = 18）婴儿之间均未表现出组间差异。然而，9个月时，与NR婴儿（n = 22）相比，ASD（n = 11）和HR-非ASD婴儿（n = 24）的PCC和纹外体显示出非典型连接。在两个样本中，连通性与症状无关。我们的研究结果表明，与ASD风险相关的网络不对称性的差异在可靠的临床诊断年龄之前是可观察的。
Autism spectrum disorder (ASD) is characterized by atypical connectivity lateralization of functional networks. However, previous studies have not directly investigated if differences in specialization between ASD and typically developing (TD) peers are present in infancy, leaving the timing of onset of these differences relatively unknown. We studied the hemispheric asymmetries of connectivity in children with ASD and infants later meeting the diagnostic criteria for ASD. Analyses were performed in 733 children with ASD and TD peers and in 71 infants at high risk (HR) or normal risk (NR) for ASD, with data collected at 1 month and 9 months of age. Comparing children with ASD (n = 301) to TDs (n = 432), four regions demonstrated group differences in connectivity: posterior cingulate cortex (PCC), posterior superior temporal gyrus, extrastriate cortex, and anterior prefrontal cortex. At 1 month, none of these regions exhibited group differences between ASD (n = 10), HR-nonASD (n = 15), or NR (n = 18) infants. However, by 9 months, the PCC and extrastriate exhibited atypical connectivity in ASD (n = 11) and HR-nonASD infants (n = 24) compared to NR infants (n = 22). Connectivity did not correlate with symptoms in either sample. Our results demonstrate that differences in network asymmetries associated with ASD risk are observable prior to the age of a reliable clinical diagnosis.
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影响因子：
10.6
作者：
Lewis JD;Evans AC;Pruett JR Jr;Botteron KN;McKinstry RC;Zwaigenbaum L;Estes AM;Collins DL;Kostopoulos P;Gerig G;Dager SR;Paterson S;Schultz RT;Styner MA;Hazlett HC;Piven J;Infant Brain Imaging Study Network
通讯作者：
Infant Brain Imaging Study Network
影响因子：
17.1
作者：
Emerson RW;Adams C;Nishino T;Hazlett HC;Wolff JJ;Zwaigenbaum L;Constantino JN;Shen MD;Swanson MR;Elison JT;Kandala S;Estes AM;Botteron KN;Collins L;Dager SR;Evans AC;Gerig G;Gu H;McKinstry RC;Paterson S;Schultz RT;Styner M;IBIS Network;Schlaggar BL;Pruett JR Jr;Piven J
通讯作者：
Piven J
影响因子：
9.9
作者：
Lee HW;Arora J;Papademetris X;Tokoglu F;Negishi M;Scheinost D;Farooque P;Blumenfeld H;Spencer DD;Constable RT
通讯作者：
Constable RT
影响因子：
3
作者：
Joshi A;Scheinost D;Okuda H;Belhachemi D;Murphy I;Staib LH;Papademetris X
通讯作者：
Papademetris X
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.