The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder.
The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder.
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DOI：
10.1016/j.biopsych.2017.03.006
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发表时间：
2017-08-01
影响因子：
10.6
通讯作者：
Infant Brain Imaging Study Network
中科院分区：
文献类型：
--
作者：
Lewis JD;Evans AC;Pruett JR Jr;Botteron KN;McKinstry RC;Zwaigenbaum L;Estes AM;Collins DL;Kostopoulos P;Gerig G;Dager SR;Paterson S;Schultz RT;Styner MA;Hazlett HC;Piven J;Infant Brain Imaging Study Network
自闭症谱系障碍(ASD)是一种发育障碍，由生命最初几年出现的行为特征定义。研究表明，大脑连接的异常与这些行为特征有关。然而，将超过定义行为开始年龄的个体包括在内，使对观察到的异常的解释变得复杂：它们可能是早期神经病理和行为异常的级联效应。我们最近对一组有ASD高、低家族风险的24个月大婴儿的网络效率进行的研究减少了这一困惑；我们报告了被归类为ASD的幼儿网络效率降低。目前的研究描绘了这些低效率在生命的第一年出现的情况。这项研究利用了260名6个月和12个月大的婴儿的数据，其中包括116名具有纵向数据的婴儿。与我们之前的研究一样，我们使用扩散数据来测量大脑区域之间连接的长度和强度，以便计算网络效率。我们在由Akaike信息标准确定的线性混合效应模型中评估组内的效率差异。在6个月后被归类为自闭症的高危婴儿中，低水平感觉处理的区域被检测到效率低下。此外，在高危婴儿中，这些低效预测了24个月的症状严重程度。这些结果表明，患有自闭症的婴儿，甚至在6个月大之前，就有与低水平处理相关的连接性缺陷，这有助于影响大脑组织的发育级联，并最终影响更高水平的认知过程和社会行为。
Autism Spectrum Disorder (ASD) is a developmental disorder defined by behavioural features that emerge during the first years of life. Research indicates that abnormalities in brain connectivity are associated with these behavioural features. However, inclusion of individuals past the age of onset of the defining behaviours complicates interpretation of the observed abnormalities: they may be cascade effects of earlier neuropathology and behavioural abnormalities. Our recent study of network efficiency in a cohort of 24-month-olds at high and low familial risk for ASD reduced this confound; we reported reduced network efficiencies in toddlers classified as ASD. The current study maps the emergence of these inefficiencies in the first year of life. The study utilizes data from 260 infants at 6 and 12 months of age, including 116 infants with longitudinal data. As in our earlier study, we use diffusion data to obtain measures of the length and strength of connections between brain regions in order to compute network efficiency. We assess group differences in efficiency within linear mixed-effects models determined by the Akaike information criterion. Inefficiencies in high-risk infants later classified as ASD were detected from 6 months onward in regions involved in low-level sensory processing. Additionally, within the high-risk infants, these inefficiencies predicted 24-month symptom severity. These results suggest that infants with ASD, even before 6 months of age, have deficits in connectivity related to low-level processing, which contribute to a developmental cascade affecting brain organization, and eventually higher-level cognitive processes and social behaviour.
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DOI：
10.1016/s0270-4684(85)80005-7
发表时间：
1985-01-01
期刊：
ANALYSIS AND INTERVENTION IN DEVELOPMENTAL DISABILITIES
影响因子：
--
作者：
FENSKE, EC;ZALENSKI, S;MCCLANNAHAN, LE
通讯作者：
MCCLANNAHAN, LE
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
3.9
作者：
Gotham, Katherine;Pickles, Andrew;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1111/j.1469-7610.2009.02153.x
发表时间：
2010-03-01
影响因子：
7.6
作者：
Belmonte, Matthew K.;Gomot, Marie;Baron-Cohen, Simon
通讯作者：
Baron-Cohen, Simon