A Role for Cyclosporin A in the Treatment of Insulin‐dependent Diabetes Mellitus?
A Role for Cyclosporin A in the Treatment of Insulin‐dependent Diabetes Mellitus?
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环孢素 A 在治疗胰岛素依赖型糖尿病中的作用？
DOI：
10.1111/j.1464-5491.1985.tb00679.x
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发表时间：
1985
影响因子：
3.5
通讯作者：
T. Mandrup
中科院分区：
文献类型：
--
作者：
J. Nerup;K. Bendtzen;T. Mandrup
1922年胰岛素的发现使人们有可能挽救胰岛素依赖型糖尿病（IDDM）患者的生命，否则这些患者肯定会早死。然而，胰岛素替代治疗并不能确保IDDM患者的正常寿命，微血管和大血管并发症的发展仍然危及IDDM患者的生命。1随着时间的推移，相对死亡率的降低，预后得到了相当大的改善。2然而，IDDM仍然受到相对死亡率相当大的增加的影响，特别是在儿童期起病的IDDM。值得警惕的是，在确诊后的前5-10年内，胰岛素依赖型糖尿病的相对死亡率仍增加2 - 3倍。近年来，胰岛素泵强化胰岛素替代治疗已证明，长期接近正常的代谢是可能的。然而，即使在早期阶段，是否可以阻止或逆转已建立的微血管并发症的进展仍值得怀疑。从诊断开始的强化胰岛素替代治疗是否能使患者获得正常的寿命和无糖尿病并发症，还有待观察。经过60多年的不断发展，胰岛素替代疗法远不是一种完美的治疗方法。
The discovery of insulin in 1922 made it possible to save the lives of patients with insulin-dependent diabetes mellitus (IDDM) otherwise condemned to certain early death. Replacement therapy with insulin, however, did not ensure IDDM patients normal longevity, and life with IDDM is still endangered by the development of microand macrovascular complications.1 Considerable improvement in prognosis, as measured by decreasing relative mortality, has occurred with time.2 Nevertheless, IDDM is still burdened by a considerable increase in relative mortality, especially with onset of IDDM in childhood. It is alarming that the relative mortality in IDDM is still increased by a factor of two to three during the first 5-10 years after diagn0sis.3.~ Recently, intensified insulin replacement therapy by pumps has demonstrated that long-term near-normalization of metabolism is pos~ible.~ It is, however, doubtful whether the progression of established microvascular complications can be arrested or reversed even at an early stage. It remains to be seen if intensive insulin replacement therapy from the time of diagnosis will provide patients with normal longevity and freedom from diabetic complications. Replacement therapy with insulin is thus far from being a perfect treatment for IDDM patients, after more than sixty years' attempts of continuing development.
双胎胰腺移植：I型糖尿病发病机制的逆转和重演。
DOI：
--
发表时间：
1984
期刊：
Transactions of the Association of American Physicians
影响因子：
--
作者：
Sutherland,DE;Sibley,R;Xu,XZ;Michael,A;Srikanta,AM;Taub,F;Najarian,J;Goetz,FC
通讯作者：
Goetz,FC
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hess,AD;Tutschka,PJ;Pu,Z;Santos,GW
通讯作者：
Santos,GW
I 型糖尿病中携带 Ia 抗原的循环 T 细胞增加。
DOI：
10.1056/nejm198204013061305
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jackson,RA;Morris,MA;Haynes,BF;Eisenbarth,GS
通讯作者：
Eisenbarth,GS