Anti-C1q antibodies in systemic lupus erythematosus.
Anti-C1q antibodies in systemic lupus erythematosus.
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DOI：
10.1177/0961203314547791
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发表时间：
2015-01
期刊：
影响因子：
2.6
通讯作者：
Petri M
中科院分区：
文献类型：
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作者：
Orbai AM;Truedsson L;Sturfelt G;Nived O;Fang H;Alarcón GS;Gordon C;Merrill J;Fortin PR;Bruce IN;Isenberg DA;Wallace DJ;Ramsey-Goldman R;Bae SC;Hanly JG;Sanchez-Guerrero J;Clarke AE;Aranow CB;Manzi S;Urowitz MB;Gladman DD;Kalunian KC;Costner MI;Werth VP;Zoma A;Bernatsky S;Ruiz-Irastorza G;Khamashta MA;Jacobsen S;Buyon JP;Maddison P;Dooley MA;Van Vollenhoven RF;Ginzler E;Stoll T;Peschken C;Jorizzo JL;Callen JP;Lim SS;Fessler BJ;Inanc M;Kamen DL;Rahman A;Steinsson K;Franks AG Jr;Sigler L;Hameed S;Pham N;Brey R;Weisman MH;McGwin G Jr;Magder LS;Petri M
在以往的研究中，抗c1q与系统性红斑狼疮（SLE）和狼疮肾炎有关。我们在一项国际多中心研究中研究了SLE（与风湿病对照）的抗c1q特异性及其与SLE表现的关系。在一项横断面研究中获得了来自25个临床站点的SLE （n=308）和其他风湿病（n=389）患者的信息和血液样本（84%为女性，68%为白种人，17%为非洲人后裔，8%为亚洲人，7%为其他）。ELISA法检测胶原样区IgG抗c1q抗体水平。SLE患者的抗c1q患病率为28%(86/308)，对照组为13% (49/389)（OR=2.7, 95% CI: 1.8-4, p<0.001）。抗c1q与蛋白尿（OR=3.0, 95% CI: 1.7-5.1, p<0.001）、红细胞铸型（OR=2.6, 95% CI: 1.2-5.4, p=0.015）、抗dsdna （OR=3.4, 95% CI: 1.9-6.1, p<0.001）和抗smith （OR=2.8, 95% CI: 1.5-5.0, p=0.01）相关。经人口统计学、ANA、抗dsdna和低补体校正后，抗c1q与肾脏受累独立相关（OR=2.3, 95% CI: 1.3-4.2, p<0.01）。同时，抗c1q、抗dsdna和低补体阳性与肾脏受累密切相关（OR=14.9, 95% CI: 5.8 ~ 38.4, p<0.01）。抗- c1q在SLE患者和亚洲种族/民族患者中更为常见。我们证实了抗c1q与肾脏受累的显著关联，独立于人口统计学和其他血清学。抗c1q联合抗dsdna和低补体与肾脏受累的血清学相关性最强。这些数据支持抗c1q在SLE，尤其是狼疮肾炎中的有效性。
Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs. rheumatic disease controls) and the association with SLE manifestations in an international multi-center study. Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p<0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p<0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p<0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p<0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p<0.01). Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis.
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影响因子：
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作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
影响因子：
6.1
作者：
Fang, Qi-Ying;Yu, Feng;Zhao, Ming-hui
通讯作者：
Zhao, Ming-hui
影响因子：
2.1
作者：
Braun, A.;Sis, J.;Andrassy, K.
通讯作者：
Andrassy, K.
影响因子：
2.1
作者：
Nived, O.;Hallengren, C. S.;Bengtsson, A. A.
通讯作者：
Bengtsson, A. A.
影响因子：
--
作者：
Trad, B.;Ben Hassine, H.;Sghiri, R.
通讯作者：
Sghiri, R.