A comparative study of trabecular bone micro-structural measurements using different CT modalities.
A comparative study of trabecular bone micro-structural measurements using different CT modalities.
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使用不同CT模式测量松质骨显微结构的比较研究。
DOI：
10.1088/1361-6560/abc367
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发表时间：
2020-11-27
影响因子：
3.5
通讯作者：
Saha PK
中科院分区：
文献类型：
--
作者：
Guha I;Klintström B;Klintström E;Zhang X;Smedby Ö;Moreno R;Saha PK
骨质疏松症，其特征在于骨矿物质密度（BMD）降低和微结构退化，显着增加骨质疏松症的风险。骨小梁显微成像有几种可行的方法，它们在技术、重建原理、空间和时间分辨率方面差异很大。此外，存在用于计算代表性骨微结构特征的不同方法。我们已经进行了尸检研究，以评估不同的方法，CT为基础的骨小梁显微结构测量。使用micro-CT和四种体内CT成像模式（HR-pQCT、牙科CBCT、全身MDCT和四肢CBCT）扫描桡骨远端的尸体骨标本。使用体内模式通过CT扫描计算松质骨微观结构测量值，并检查其与微型CT成像的相应参考测量值的一致性。提出了一种新的算法来优化软阈值参数，用于计算骨体积分数图像的个体CT模式。体内CT模式的大多数骨小梁测量值（包括骨小梁体积、网络面积、横向和板-棒显微结构、厚度和间距）的观察值均高于来自显微CT成像的参考值。一般而言，与其他体内CT模式相比，HR-pQCT成像得出的骨小梁测量值更接近其参考值。尽管不同模态之间测量的观察值存在很大差异，但在骨小梁体积、横向和板微结构体积以及网络面积的显微CT和体内CT衍生测量之间发现了高度线性相关性（r ∈ [0.94 0.99]）。除侵蚀指数外，所有HR-pQCT衍生的小梁测量均显示出高度相关性（r ∈ [0.91 0.99]）。与板宽测量（r ∈ [0.72 0.91]）相比，使用体内模式的侵蚀指数显示出较弱的相关性（r ∈ [0.65 0.81]）。发现的强相关性证明了体内CT模式用于骨小梁显微结构成像的潜力。然而，在体内成像方式的骨小梁测量的观察值的大的变化表明，适当的扫描仪校准是必要的，然后才使用在多部位和纵向研究。不同的成像模式的不同措施的广泛的性能表明，需要一个明智的选择措施，这取决于所使用的成像模式。
Osteoporosis, characterized by reduced bone mineral density (BMD) and micro-architectural degeneration, significantly enhances fracture-risk. There are several viable methods for trabecular bone micro-imaging, which widely vary in terms of technology, reconstruction principle, spatial and temporal resolutions. Also, there are different methods for computing representative bone micro-structural features. We have performed a post-mortem study to evaluate different methods of CT-based trabecular bone micro-structural measurements. Cadaveric bone specimens from the distal radius were scanned using micro-CT and four in vivo CT imaging modalities: HR-pQCT, dental CBCT, whole body MDCT, and extremity CBCT. Trabecular bone micro-structural measures were computed from CT scans using in vivo modalities, and their agreement with corresponding reference measures from micro-CT imaging was examined. A new algorithm was developed to optimize soft thresholding parameters for individual CT modalities for computing bone volume fraction images. Observed values of most trabecular measures, including trabecular bone volume, network area, transverse and plate-rod micro-structure, thickness, and spacing, for in vivo CT modalities were higher than their reference values derived from micro-CT imaging. In general, the values of trabecular bone measures derived from HR-pQCT imaging were closer to their reference values as compared to other in vivo CT modalities. Despite large differences in observed values of measures among modalities, high linear correlation (r ∈ [0.94 0.99]) was found among micro-CT and in vivo CT-derived measures of trabecular bone volume, transverse and plate micro-structural volume, and network area. All HR-pQCT-derived trabecular measures, except erosion index, showed high correlation (r ∈ [0.91 0.99]). Erosion index using in vivo modalities showed weaker correlation (r ∈ [0.65 0.81]) as compared to the plate-width measure (r ∈ [0.72 0.91]). The strong correlations found, demonstrate the potential of in vivo CT modalities for trabecular bone micro-structural imaging. However, large shifts in observed values of trabecular bone measures for in vivo imaging modalities suggest that proper scanner calibration is necessary before using in multisite and longitudinal studies. The wide range of performance of different measures with different imaging modalities suggests the need for a judicious choice of measures depending on the imaging modality used.
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影响因子：
3.7
作者：
Klintstrom, Eva;Klintstrom, Benjamin;Smedby, Orjan
通讯作者：
Smedby, Orjan
影响因子：
6.2
作者：
Boutroy, Stephanie;Van Rietbergen, Bert;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
1.4
作者：
Moon, HS;Won, YY;Chung, MK
通讯作者：
Chung, MK
DOI：
10.1111/j.1445-5994.1992.tb02124.x
发表时间：
1992-06-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE
影响因子：
--
作者：
MOORE, RJ;DURBRIDGE, TC;VERNONROBERTS, B
通讯作者：
VERNONROBERTS, B
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD