Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei.
Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei.
复制标题
DOI：
10.1016/j.neulet.2011.05.011
复制
发表时间：
2011-07-12
影响因子：
2.5
通讯作者：
Choi S
中科院分区：
文献类型：
--
作者：
Boisvert JP;Boschuetz TJ;Resch JM;Mueller CR;Choi S
Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 μl/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine’s effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT1-2 receptor antagonist, metergoline (15 nmol/0.5 μl/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake.
登录
查看更多内容
影响因子：
4.7
作者：
Clemett, DA;Punhani, T;Fone, KCF
通讯作者：
Fone, KCF
影响因子：
2.9
作者：
Choi, SJ;Jonak, EM;Fernstrom, JD
通讯作者：
Fernstrom, JD
影响因子：
3.4
作者：
NEILL, JC;COOPER, SJ
通讯作者：
COOPER, SJ
影响因子：
2.9
作者：
LEFEUVRE, RA;AISENTHAL, L;ROTHWELL, NJ
通讯作者：
ROTHWELL, NJ
影响因子：
3.4
作者：
Hayashi, A;Suzuki, M;Miyata, K
通讯作者：
Miyata, K