Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and l-DOPA treatment
Dopamine D3 receptors in the basal ganglia of the common marmoset and following MPTP and l-DOPA treatment
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普通狨猴基底神经节中的多巴胺 D3 受体以及 MPTP 和 l-DOPA 治疗后的情况
DOI：
10.1016/0006-8993(95)01309-1
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发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
C. Marsden
中科院分区：
文献类型：
--
作者：
M. J. Hurley;J. Jolkkonen;C. M. Stubbs;P. Jenner;C. Marsden
用[~ 3 H]7-OH-DPAT受体放射自显影法研究了普通绒猴（Callithrix jacchus）纹状体和纹状体外脑区多巴胺D_3受体的分布。饱和度研究表明，[3 H]7-OH-DPAT与绒猴脑不同区域的结合亲和力相似。在正常的绒猴，特异性[3 H]7-OH-DPAT结合被发现在纹状体和纹状体外区。在Calleja岛和延髓核中检测到非常高水平的特异性[3 H]7-OH-DPAT结合，但在头侧尾状核和壳核中检测到高水平的结合。用选择性黑质神经毒素1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）处理普通绒猴，纹状体和纹状体外区特异性[3 H]7-OH-DPAT结合水平与正常动物无差异。用l-多巴/卡比多巴对MPTP处理的绒猴进行慢性治疗，没有改变任何脑区中特异性[3 H]7-OH-DPAT结合的水平。这些结果表明，在普通的绒猴D3受体位于纹状体和边缘区。受体密度不改变多巴胺能去神经支配或长期左旋多巴管理。因此，D3受体可能在用于治疗帕金森病的药物的治疗和不良反应中都很重要。
The distribution of the dopamine D3 receptor was studied by receptor autoradiography using [3H]7-OH-DPAT in striatal and extrastriatal brain regions of the common marmoset (Callithrix jacchus). Saturation studies demonstrated that [3H]7-OH-DPAT bound with similar affinity to different regions of marmoset brain. In normal marmosets, specific [3H]7-OH-DPAT binding was found in both striatal and extrastriatal regions. Very high levels of specific [3H]7-OH-DPAT binding were detected in the islands of Calleja and nucleus accumbens but in addition high levels of binding were detected in rostral caudate nucleus and putamen. In common marmosets treated with the selective nigral neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the levels of specific [3H]7-OH-DPAT binding in striatal and extrastriatal regions were not different to those in normal animals. Chronic treatment of MPTP-treated marmosets with l-DOPA/carbidopa did not alter the levels of specific [3H]7-OH-DPAT binding in any brain region. These results demonstrate that in common marmosets D3receptors are located in both striatal and limbic regions. The receptor density is not altered by dopaminergic denervation or by chronic l-DOPA administration. The D3receptor may, therefore, be important in both the therapeutic and adverse effects of drugs used to treat Parkinson's disease.
DOI：
10.1073/pnas.91.23.11271
发表时间：
1994-11-08
影响因子：
11.1
作者：
MURRAY, AM;RYOO, HL;JOYCE, JN
通讯作者：
JOYCE, JN