Non-SH2/PDZ reverse signaling by ephrins.
Non-SH2/PDZ reverse signaling by ephrins.
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DOI：
10.1016/j.semcdb.2011.10.012
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发表时间：
2012-02
影响因子：
7.3
通讯作者：
Daar, Ira O.
中科院分区：
文献类型：
--
作者：
Daar, Ira O.
我们对Eph/ephrin信号在细胞粘附和细胞运动中发挥作用的过程和信号事件的理解已经取得了很大的进步。然而，这些信号事件调节细胞和组织结构的确切机制仍需进一步研究。Eph/ephrin信号通路和调节细胞粘附和运动的能力构成了一个令人印象深刻的调节组织分离和形态发生的系统。此外，该信号系统的失调与促进人类侵袭性和转移性肿瘤有关。在下一节中，我们将讨论一些有趣的机制，通过这些机制，ephrin可以通过其自身的细胞内结构域（反向信号）独立于正向信号传导或通过同源受体进行正向信号传导。在这篇综述中，我们讨论了ephrin （Eph配体）如何通过其胞内结构域“反向信号”影响细胞粘附和运动，但重点是独立于SH2和PDZ相互作用的作用模式。
Great strides have been made regarding our understanding of the processes and signaling events influenced by Eph/ephrin signaling that play a role in cell adhesion and cell movement. However, the precise mechanisms by which these signaling events regulate cell and tissue architecture still need further resolution. The Eph/ephrin signaling pathways and the ability to regulate cell-cell adhesion and motility constitutes an impressive system for regulating tissue separation and morphogenesis. Moreover, the de-regulation of this signaling system is linked to the promotion of aggressive and metastatic tumors in humans. In the following section, we discuss some of the interesting mechanisms by which ephrins can signal through their own intracellular domains (reverse signaling) either independent of forward signaling or in addition to forward signaling through a cognate receptor. In this review we discuss how ephrins (Eph ligands) “reverse signal” through their intracellular domains to affect cell adhesion and movement, but the focus is on modes of action that are independent of SH2 and PDZ interactions.
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