Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT‐1 mRNA in the striatum
Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT‐1 mRNA in the striatum
复制标题
长期抗精神病药物治疗改变纹状体中胶质细胞谷氨酸转运蛋白 GLT-1 mRNA 的表达
作者：
J. S. Schneider;T. Wade;T. Lidsky
最近的报道表明，典型的精神抑制剂可能会增强交感神经能神经传递，这些作用可能是慢性精神抑制剂治疗的运动副作用的部分基础。由于谷氨酸再摄取是控制细胞外谷氨酸水平的主要机制，本研究进行检查是否慢性神经阻滞剂暴露改变纹状体谷氨酸转运蛋白GLT-1的基因表达。虽然氟哌啶醇和氯氮平治疗30天显着降低GLT-1的表达从正常，氟哌啶醇治疗的效果是一致的，在背侧纹状体，显着大于氯氮平。这些研究结果表明，谷氨酸转运的缺陷可能是抗精神病药引起的运动障碍的发病机制的基础。
RECENT reports have shown that typical neuroleptics may enhance glutamatergic neurotransmission and that these effects might in part underlie motor side effects of chronic neuroleptic treatment. Since glutamate reuptake is the primary mechanism for controlling extracellular glutamate levels, the present study was conducted to examine whether chronic neuroleptic exposure alters gene expression for the glutamate transporter GLT-1 in the striatum. Although both haloperidol and clozapine treatment for 30 days significantly decreased GLT-1 expression from normal, the effects of haloperidol treatment were consistently, and in the dorsal striatum, significantly greater than those of clozapine. These findings suggest that a deficiency in glutamate transport may underlie the pathogenesis of neuroleptic-induced movement disorders.
影响因子：
158.5
作者：
ROTHSTEIN, JD;MARTIN, LJ;KUNCL, RW
通讯作者：
KUNCL, RW
通过体内微透析研究慢性氯氮平和氟哌啶醇对大鼠纹状体和伏核基础多巴胺释放和代谢的影响。
影响因子：
5
作者：
Ichikawa,J;Meltzer,HY
通讯作者：
Meltzer,HY
慢性氟哌啶醇（而不是氯氮平）会改变大鼠的口腔运动并增加细胞外谷氨酸。
影响因子：
5
作者：
See,RE;Chapman,MA
通讯作者：
Chapman,MA