Genome wide association analysis of cuticle deposition in laying hens.
Genome wide association analysis of cuticle deposition in laying hens.
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DOI：
10.1016/j.psj.2023.102990
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发表时间：
2023-10
期刊：
影响因子：
4.4
通讯作者：
Wolc, Anna
中科院分区：
文献类型：
--
作者：
Wang, Zhang;Dunn, Ian C.;Wilson, Peter W.;Pertinez, Sandra Poyatos;Fulton, Janet E.;Arango, Jesus;Andersson, Bjoern;Schmutz, Matthias;Wolc, Anna
角质层是一个看不见的屏障，保护内部蛋内容物免受微生物通过气体交换孔进入。具有良好角质层的鸡蛋最不可能被微生物穿透，改善角质层覆盖应减少微生物的垂直传播并提高生物安全性。目的是利用柠檬黄和丽丝胺绿色染色对3个独立的蛋鸡群体的角质层沉积进行全基因组关联研究。来自108，000只母鸡的鸡蛋代表2只白色来航鸡和1只罗得岛红色品种。使用系谱或基因组关系矩阵估计遗传力在0.2至0.3的范围内。结果是品种特异性的。在整个种群中，染色体1，2，4，5和8上的基因组区域被鉴定为与角质层沉积显著相关。没有一个单一的基因座有很大的影响。比较差异表达的基因在壳腺角质层沉积时进行操作，但没有明显的候选角质层沉积。结果支持性状的多基因性质，这些信息将有助于未来了解遗传变异以及可能控制角质层沉积和鸡蛋微生物安全性的因素。
The cuticle is an invisible barrier that protects the internal egg contents from microorganisms entering through gas exchange pores. Eggs which have a good cuticle are least likely to be penetrated by microorganisms and improved cuticle cover should reduce vertical transmission of microorganisms and improve biosecurity. The aim was to carry out a genome wide association study for cuticle deposition in 3 independent populations of laying hens using tartrazine and lissamine green staining. Eggs from ∼8,000 hens represented 2 White Leghorn and 1 Rhode Island Red breed. Estimates of heritability using pedigree or genomic relationship matrices were in the 0.2 to 0.3 range. The results were breed specific. Across the populations, genomic regions on chromosomes 1, 2, 4, 5, and 8 were identified as significantly associated with cuticle deposition. No single loci had a large effect. A comparison was made with genes differentially expressed in the shell gland when cuticle deposition was manipulated, however none were obvious candidates for cuticle deposition. The results support the polygenic nature of the trait and the information will help in the future to understand the genetic variance and what might control cuticle deposition and the microbiological safety of the egg.
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影响因子：
4.4
作者：
Sirri F;Zampiga M;Berardinelli A
通讯作者：
Berardinelli A
影响因子：
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作者：
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