Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes.
Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes.
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DOI:
10.1192/bjp.2020.249
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发表时间:
2021-05
期刊:
影响因子:
--
通讯作者:
Luciano S
中科院分区:
文献类型:
--
作者:
Harrison PJ;Colbourne L;Luciano S
Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health records network, we compared rates of these disorders over a 2 year period in propensity score matched cohorts of people taking calcium channel blockers (CCBs) compared to those taking other AHT classes. CCBs were associated with a higher incidence of all disorders compared to renin-angiotensin system agents, and a higher incidence of dementia and cerebrovascular disease compared to diuretics. CCBs were associated with a lower incidence of movement disorders and cerebrovascular disease than with β-blockers. The data show that AHT classes confer differential risks of neurodegenerative and cerebrovascular diagnoses.
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