Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes.

Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes.
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DOI:
10.1192/bjp.2020.249
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发表时间:
2021-05
期刊:
The British journal of psychiatry : the journal of mental science
影响因子:
--
通讯作者:
Luciano S
Luciano S
中科院分区:
其他
文献类型:
--
作者:
Harrison PJ;Colbourne L;Luciano S

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抗高血压药物(AHT)与降低神经退行性疾病和中风的风险有关。然而,与不同AHT类别相关的相对风险尚不清楚。使用电子健康记录网络,我们比较了2年内服用钙通道阻滞剂(CCB)的人群与服用其他AHT类药物的人群的倾向评分匹配队列中这些疾病的发生率。与肾素-血管紧张素系统药物相比,CCB与所有疾病的发生率较高相关,与利尿剂相比,CCB与痴呆和脑血管疾病的发生率较高相关。与β受体阻滞剂相比,CCB与运动障碍和脑血管疾病的发生率较低相关。数据显示,AHT类别赋予神经退行性疾病和脑血管疾病诊断的不同风险。
Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health records network, we compared rates of these disorders over a 2 year period in propensity score matched cohorts of people taking calcium channel blockers (CCBs) compared to those taking other AHT classes. CCBs were associated with a higher incidence of all disorders compared to renin-angiotensin system agents, and a higher incidence of dementia and cerebrovascular disease compared to diuretics. CCBs were associated with a lower incidence of movement disorders and cerebrovascular disease than with β-blockers. The data show that AHT classes confer differential risks of neurodegenerative and cerebrovascular diagnoses.
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