Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.
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DOI:
10.1192/bjp.2019.157
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发表时间:
2020-05
期刊:
The British journal of psychiatry : the journal of mental science
影响因子:
--
通讯作者:
Hall J
Hall J
中科院分区:
其他
文献类型:
--
作者:
Harrison PJ;Tunbridge EM;Dolphin AC;Hall J

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我们重新评估钙通道阻滞剂(CCB)的精神治疗潜力。首先,电压门控钙通道是多种疾病的风险基因。其次,CCB 的使用与精神风险和结果的改变有关。第三,研究表明大脑选择性 CCB 有机会,它更适合精神科适应症。
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.
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