The AlphaFold Database of Protein Structures: A Biologist's Guide.
The AlphaFold Database of Protein Structures: A Biologist's Guide.
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DOI：
10.1016/j.jmb.2021.167336
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发表时间：
2022-01-30
影响因子：
5.6
通讯作者：
Sternberg MJE
中科院分区：
文献类型：
--
作者：
David A;Islam S;Tankhilevich E;Sternberg MJE
AlphaFold发布了人类蛋白质组的三维模型（3D）。准确和不好建模的区域可能存在于单个AlphaFold模型中。讨论了AlphaFold模型的优点、局限性和未解决的挑战。由DeepMind开发的深度学习算法AlphaFold最近向科学界发布了整个人类蛋白质组的三维模型。在这里，我们从生物学家的角度讨论了AlphaFold模型的优势，局限性和尚未解决的挑战，这些生物学家可能不是结构生物学专家。
AlphaFold, released the three-dimensional models (3D) of the human proteome. Accurately and poorly modelled regions may be present within a single AlphaFold model. The advantages, limitations and unsolved challenges of AlphaFold models are discussed. AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology.
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影响因子：
64.8
作者：
Tunyasuvunakool K;Adler J;Wu Z;Green T;Zielinski M;Žídek A;Bridgland A;Cowie A;Meyer C;Laydon A;Velankar S;Kleywegt GJ;Bateman A;Evans R;Pritzel A;Figurnov M;Ronneberger O;Bates R;Kohl SAA;Potapenko A;Ballard AJ;Romera-Paredes B;Nikolov S;Jain R;Clancy E;Reiman D;Petersen S;Senior AW;Kavukcuoglu K;Birney E;Kohli P;Jumper J;Hassabis D
通讯作者：
Hassabis D
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
影响因子：
14.8
作者：
Kelley LA;Mezulis S;Yates CM;Wass MN;Sternberg MJ
通讯作者：
Sternberg MJ
影响因子：
2.9
作者：
Del Alamo D;Govaerts C;Mchaourab HS
通讯作者：
Mchaourab HS
影响因子：
2.9
作者：
Millán C;Keegan RM;Pereira J;Sammito MD;Simpkin AJ;McCoy AJ;Lupas AN;Hartmann MD;Rigden DJ;Read RJ
通讯作者：
Read RJ