Chemical Exchange Saturation Transfer (CEST) MR Technique for Liver Imaging at 3.0 Tesla: an Evaluation of Different Offset Number and an After-Meal and Over-Night-Fast Comparison.
Chemical Exchange Saturation Transfer (CEST) MR Technique for Liver Imaging at 3.0 Tesla: an Evaluation of Different Offset Number and an After-Meal and Over-Night-Fast Comparison.
复制标题
DOI：
10.1007/s11307-015-0887-8
复制
发表时间：
2016-04
影响因子：
3.1
通讯作者：
Wáng YX
中科院分区：
文献类型：
--
作者：
Deng M;Chen SZ;Yuan J;Chan Q;Zhou J;Wáng YX
To explore whether Chemical Exchange Saturation Transfer (CEST) MRI can detect liver composition changes between after-meal and over-night-fast statuses. 15 healthy volunteers were scanned on a 3.0 T human MRI scanner in the evening 1.5–2 hour after dinner and in the morning after over-night (12-hour) fasting. Among them seven volunteers were scanned twice to assess the scan-rescan reproducibility. Images were acquired at offsets (n=41, increment=0.25ppm) from −5 to 5ppm using a turbo spin echo (TSE) sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified with the asymmetric magnetization transfer ratio (MTRasym) at 3.5ppm and the total MTRasym integrated from 0.5 to 1.5ppm from the corrected Z-spectrum, respectively. To explore scan time reduction, CEST images were reconstructed using 31 offsets (with 20% time reduction) and 21 offsets (with 40% time reduction), respectively. For reproducibility, GlycoCEST measurements in 41 offsets showed the smallest scan-rescan mean measurements variability, indicated by lowest mean difference of −0.049% (95% limits of agreement: −0.209% to 0.111%); for APTw, the smallest mean difference was found to be 0.112% (95% limits of agreement: −0.698% to 0.921%) in 41 offsets. Compared with after-meal, both GlycoCEST measurement and APTw measurement under different offset number decreased after 12-hour fasting. However, as the offsets number decreased (41 offsets vs. 31 offsets vs. 21 offsets), GlycoCEST map and APTw map became more heterogeneous and noisier. Our results show that CEST liver imaging at 3.0 T has high sensitivity for fasting.
登录
查看更多内容
DOI：
10.3978/j.issn.2223-4292.2014.04.12
发表时间：
2014-04-01
影响因子：
2.8
作者：
Pang, Yong;Jiang, Xiaohua;Zhang, Xiaoliang
通讯作者：
Zhang, Xiaoliang
影响因子：
5.9
作者：
Haneder, Stefan;Apprich, Sebastian R.;Trattnig, Siegfried
通讯作者：
Trattnig, Siegfried
影响因子：
19.7
作者：
Salameh, Najat;Larrat, Benoit;Van Beers, Bernard E.
通讯作者：
Van Beers, Bernard E.
影响因子：
5.7
作者：
Jones, Craig K.;Huang, Alan;Xu, Jiadi;Edden, Richard A. E.;Schaer, Michael;Hua, Jun;Oskolkov, Nikita;Zaca, Domenico;Zhou, Jinyuan;McMahon, Michael T.;Pillai, Jay J.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
2.6
作者：
Deng, M.;Zhao, F.;Wang, Y-X J.
通讯作者：
Wang, Y-X J.