From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic Tumorigenesis.
From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic Tumorigenesis.
复制标题
DOI：
10.3390/ijms19113584
复制
发表时间：
2018-11-13
影响因子：
5.6
通讯作者：
Pan MR
中科院分区：
文献类型：
--
作者：
Wang HC;Hung WC;Chen LT;Pan MR
胰腺导管腺癌（PDAC）是一种致死性疾病，5年生存率约为8%。超过80%的患者由于转移或局部扩展而在不可切除的阶段被诊断。通过免疫疗法重新激活患者的免疫系统可以消除肿瘤细胞，是癌症治疗的新策略。抗CTLA-4抗体伊匹单抗和抗PD-1抗体派姆单抗和纳武单抗已在不同国家被批准用于癌症治疗。然而，免疫治疗PDAC的结果并不令人满意。低应答率可能是由于免疫原性差，胰腺癌细胞中的肿瘤突变负荷低，以及阻止免疫细胞在肿瘤中积聚的结缔组织增生。PDAC中的免疫抑制肿瘤微环境在肿瘤进展和治疗抗性中是重要的。从免疫耐受到免疫激活状态的转换对于克服癌症中的自我防御能力至关重要。因此，彻底阐明各种免疫相关因子、肿瘤微环境和肿瘤细胞在PDAC发展中的作用，可能为靶向炎症通路激活作为预防和治疗这种癌症的新治疗策略提供适当的方向。
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a 5-year survival rate of approximately 8%. More than 80% of patients are diagnosed at an unresectable stage due to metastases or local extension. Immune system reactivation in patients by immunotherapy may eliminate tumor cells and is a new strategy for cancer treatment. The anti-CTLA-4 antibody ipilimumab and anti-PD-1 antibodies pembrolizumab and nivolumab have been approved for cancer therapy in different countries. However, the results of immunotherapy on PDAC are unsatisfactory. The low response rate may be due to poor immunogenicity with low tumor mutational burden in pancreatic cancer cells and desmoplasia that prevents the accumulation of immune cells in tumors. The immunosuppressive tumor microenvironment in PDAC is important in tumor progression and treatment resistance. Switching from an immune tolerance to immune activation status is crucial to overcome the inability of self-defense in cancer. Therefore, thoroughly elucidation of the roles of various immune-related factors, tumor microenvironment, and tumor cells in the development of PDAC may provide appropriate direction to target inflammatory pathway activation as a new therapeutic strategy for preventing and treating this cancer.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
5.5
作者：
Cereda, Vittore;Vergati, Matteo;Huen, Ngar-Yee;di Bari, Maria Giovanna;Jochems, Caroline;Intrivici, Chiara;Gulley, James L.;Apelian, David;Schlom, Jeffrey;Tsang, Kwong Y.
通讯作者：
Tsang, Kwong Y.
PD-1检查点途径的分子和生化方面。
DOI：
10.1056/nejmra1514296
发表时间：
2016-11-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boussiotis VA
通讯作者：
Boussiotis VA
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
4.4
作者：
Bronte, V;Serafini, P;Zanovello, P
通讯作者：
Zanovello, P