Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.
Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.
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DOI：
10.1088/1361-6560/aa5f48
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发表时间：
2017-05-07
影响因子：
3.5
通讯作者：
Conolly SM
中科院分区：
文献类型：
--
作者：
Keselman P;Yu EY;Zhou XY;Goodwill PW;Chandrasekharan P;Ferguson RM;Khandhar AP;Kemp SJ;Krishnan KM;Zheng B;Conolly SM
磁粒子成像(MPI)是一种新兴的基于示踪剂的医学成像方式，它对非放射性、肾脏安全的超顺磁性氧化铁(SPIO)示踪剂进行成像。MPI提供定量、高对比度和高信噪比的图像，因此MPI在细胞跟踪、血管成像、脑血流灌注、癌症检测、创伤性脑损伤和肺部成像等应用方面具有特殊的前景。在评估MPI在上述应用中的效用时，重要的是能够评估示踪剂的短期生物分布以及从体内的长期清除。这里，我们描述了MPI中两种常用示踪剂的生物分布和清除情况：Ferucarbotran(Meito Sangyo Co.，日本)和LS-OO8(LodeSpin Labs，Seattle，WA)。我们成功地证明了3D MPI能够定量评估这些示踪剂在体内的短期生物分布以及长期跟踪和清除。
Magnetic Particle Imaging (MPI) is an emerging tracer-based medical imaging modality that images non-radioactive, kidney-safe superparamagnetic iron oxide (SPIO) tracers. MPI offers quantitative, high-contrast and high-SNR images, so MPI has exceptional promise for applications such as cell tracking, angiography, brain perfusion, cancer detection, traumatic brain injury and pulmonary imaging. In assessing MPI's utility for applications mentioned above, it is important to be able to assess tracer short-term biodistribution as well as long-term clearance from the body. Here, we describe the biodistribution and clearance for two commonly used tracers in MPI: Ferucarbotran (Meito Sangyo Co., Japan) and LS-oo8 (LodeSpin Labs, Seattle, WA). We successfully demonstrate that 3D MPI is able to quantitatively assess short-term biodistribution, as well as long-term tracking and clearance of these tracers in vivo.
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影响因子：
17.1
作者：
Gu L;Fang RH;Sailor MJ;Park JH
通讯作者：
Park JH
影响因子：
3.7
作者：
Antonelli, Antonella;Sfara, Carla;Magnani, Mauro
通讯作者：
Magnani, Mauro
影响因子：
16.1
作者：
Janib, Siti M.;Moses, Ara S.;MacKay, J. Andrew
通讯作者：
MacKay, J. Andrew
影响因子：
3.8
作者：
Ferguson, R. Matthew;Minard, Kevin R.;Krishnan, Kannan M.
通讯作者：
Krishnan, Kannan M.
影响因子：
1.3
作者：
Lawaczeck, R;Bauer, H;Weinmann, HJ
通讯作者：
Weinmann, HJ