miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block.
miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block.
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DOI：
10.1007/s12265-022-10318-w
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发表时间：
2023-04
影响因子：
3.4
通讯作者：
Reddy, Sushma
中科院分区：
文献类型：
--
作者：
Navarre, Brittany M.;Clouthier, Katie L.;Ji, Xuhuai;Taylor, Anne;Weldy, Chad S.;Dubin, Anne M.;Reddy, Sushma
慢性心室起搏可导致起搏诱导的心肌病（PICM）。临床数据本身不足以预测谁会发展PICM。我们的研究旨在评估与先天性完全性房室传导阻滞（CCAVB）儿童慢性右心室起搏相关的循环miR谱，并确定纵向监测的候选miR。从长期起搏儿童（N = 9）中收集临床数据和血液，并与非起搏对照组（N = 13）进行比较。来自血沉棕黄层的miR微阵列揭示了组间488个差异调节的miR。通路分析预测了适应性和适应不良的miR信号传导与慢性起搏相关，尽管保留了心室功能。在起搏> 10年的患者中观察到更大的促纤维化信号传导（miR-92 a，130，27，29）以及钠和钙通道失调（let-7），其中在猝死患者中观察到的最大失调与起搏< 10年的患者相比。这些miR可能有助于识别该人群的早期不良重塑。在线版本包含补充材料，可通过10.1007/s12265-022-10318-w获得。
Chronic ventricular pacing can lead to pacing-induced cardiomyopathy (PICM). Clinical data alone is insufficient to predict who will develop PICM. Our study aimed to evaluate the circulating miR profile associated with chronic right ventricular pacing in children with congenital complete AV block (CCAVB) and to identify candidate miRs for longitudinal monitoring. Clinical data and blood were collected from chronically paced children (N = 9) and compared with non-paced controls (N = 13). miR microarrays from the buffy coat revealed 488 differentially regulated miRs between groups. Pathway analysis predicted both adaptive and maladaptive miR signaling associated with chronic pacing despite preserved ventricular function. Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. These miRs may help to identify early adverse remodeling in this population. The online version contains supplementary material available at 10.1007/s12265-022-10318-w.
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影响因子：
4.6
作者：
Gholaminejad, Alieh;Zare, Nasrin;Javanmard, Shaghayegh Haghjooy
通讯作者：
Javanmard, Shaghayegh Haghjooy
影响因子：
37.8
作者：
Nield, LE;Silverman, ED;Hornberger, LK
通讯作者：
Hornberger, LK
影响因子：
4.6
作者：
Mompeon, Ana;Ortega-Paz, Luis;Hermenegildo, Carlos
通讯作者：
Hermenegildo, Carlos
DOI：
10.1111/j.1540-8159.1999.tb00631.x
发表时间：
1999-09-01
影响因子：
1.8
作者：
Karpawich, PP;Rabah, R;Haas, JE
通讯作者：
Haas, JE
影响因子：
3.7
作者：
Glinge C;Clauss S;Boddum K;Jabbari R;Jabbari J;Risgaard B;Tomsits P;Hildebrand B;Kääb S;Wakili R;Jespersen T;Tfelt-Hansen J
通讯作者：
Tfelt-Hansen J