Mouse Models of Germinal Center Derived B-Cell Lymphomas.
Mouse Models of Germinal Center Derived B-Cell Lymphomas.
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DOI：
10.3389/fimmu.2021.710711
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发表时间：
2021
影响因子：
7.3
通讯作者：
Pasqualucci L
中科院分区：
文献类型：
--
作者：
Meyer SN;Koul S;Pasqualucci L
在过去的几十年里，DNA测序的革命改变了我们理解B细胞淋巴瘤遗传学和生物学的方式，发现了大量反复突变的基因，这些基因的异常功能可能在这些癌症的发生和/或维持中发挥重要作用。剖析相关基因如何影响生发中心 (GC) B 细胞（大多数 B 细胞淋巴瘤的起源）的生理学和病理学，将是提高我们诊断和治疗这些患者的能力的关键。基因工程小鼠模型（GEMM）忠实地再现了淋巴瘤相关的基因改变，为研究候选癌基因和肿瘤抑制因子在体内的致病作用提供了一个有价值的平台，并在完整的肿瘤免疫微环境的背景下临床前开发新的治疗原理。在这篇综述中，我们总结了通过准确建模人类 GC B 细胞恶性肿瘤中最常见的遗传改变而获得的最先进的 GEMM，重点关注伯基特淋巴瘤、滤泡性淋巴瘤和弥漫性大 B 细胞淋巴瘤，并讨论从这些模型中吸取的经验教训如何帮助指导该疾病的新型治疗方法的设计。
Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells –the origin of most B-cell lymphomas– will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors in vivo, and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. In this review, we provide a summary of state-of-the art GEMMs obtained by accurately modelling the most common genetic alterations found in human GC B cell malignancies, with a focus on Burkitt lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma, and we discuss how lessons learned from these models can help guide the design of novel therapeutic approaches for this disease.
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影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
8
作者：
Butzler, C;Zou, XG;Bruggemann, M
通讯作者：
Bruggemann, M
影响因子：
50.3
作者：
Calado DP;Zhang B;Srinivasan L;Sasaki Y;Seagal J;Unitt C;Rodig S;Kutok J;Tarakhovsky A;Schmidt-Supprian M;Rajewsky K
通讯作者：
Rajewsky K
影响因子：
50.3
作者：
Brescia P;Schneider C;Holmes AB;Shen Q;Hussein S;Pasqualucci L;Basso K;Dalla-Favera R
通讯作者：
Dalla-Favera R
影响因子：
10.1
作者：
Ba Z;Meng FL;Gostissa M;Huang PY;Ke Q;Wang Z;Dao MN;Fujiwara Y;Rajewsky K;Zhang B;Alt FW
通讯作者：
Alt FW