TGFβ signalling in context.

TGFβ signalling in context.
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TGFβ 信号的背景

DOI:
10.1038/nrm3434
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发表时间:
2012-10
期刊:
Nature reviews. Molecular cell biology
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其他
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转化生长因子-β (tgf -β)途径的基本原理在十多年前就被揭示出来。从那时起,TGFβ信号如何从细胞膜传播到细胞核的概念随着其他发现而丰富,其多功能性质和医学相关性不断曝光。然而,一个古老的谜团一直存在:环境如何决定细胞对tgf - β的反应?解决这个问题是理解tgf - β生物学及其许多功能失调的关键。最近的进展指向了答案。
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.
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