Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets.
Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets.
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DOI：
10.1084/jem.20170494
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发表时间：
2017-07-03
期刊：
影响因子：
--
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Fang D;Zhu J
Fang和Zhu讨论了CD4 T细胞和ILC亚群之间的异同，以及决定这些亚群异质性和可塑性的主要转录因子。CD4 T细胞，包括T调节细胞（Treg细胞）和效应T辅助细胞（Th细胞），以及最近发现的先天淋巴样细胞（ILCs）在宿主防御和炎症中发挥重要作用。CD4 T细胞和ILCs都可以根据其功能和谱系特异性基因的表达分为不同的谱系，包括编码效应细胞因子、细胞表面标记物和关键转录因子的基因。人们首先认识到，每个谱系表达一个特定的主转录因子，由于这些因子之间的交叉调节，这些因子的表达是相互排斥的。然而，最近的研究表明，主调控因子通常是共表达的。此外，主调节器的表达可以是动态的和定量的。在这篇综述中，我们将首先讨论CD4 T细胞和ILC亚群的发育和功能之间的异同，然后总结最近关于决定这些亚群异质性和可塑性的主要转录因子之间定量、动态和细胞类型特异性平衡的文献。
Fang and Zhu discuss similarities and differences between CD4 T cell and ILC subsets and the master transcription factors that determine the heterogeneity and plasticity of these subsets. CD4 T cells, including T regulatory cells (Treg cells) and effector T helper cells (Th cells), and recently identified innate lymphoid cells (ILCs) play important roles in host defense and inflammation. Both CD4 T cells and ILCs can be classified into distinct lineages based on their functions and the expression of lineage-specific genes, including those encoding effector cytokines, cell surface markers, and key transcription factors. It was first recognized that each lineage expresses a specific master transcription factor and the expression of these factors is mutually exclusive because of cross-regulation among these factors. However, recent studies indicate that the master regulators are often coexpressed. Furthermore, the expression of master regulators can be dynamic and quantitative. In this review, we will first discuss similarities and differences between the development and functions of CD4 T cell and ILC subsets and then summarize recent literature on quantitative, dynamic, and cell type–specific balance between the master transcription factors in determining heterogeneity and plasticity of these subsets.
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影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
DOI：
10.4049/jimmunol.1300379
发表时间：
2013-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Furusawa J;Moro K;Motomura Y;Okamoto K;Zhu J;Takayanagi H;Kubo M;Koyasu S
通讯作者：
Koyasu S
影响因子：
32.4
作者：
Califano D;Cho JJ;Uddin MN;Lorentsen KJ;Yang Q;Bhandoola A;Li H;Avram D
通讯作者：
Avram D
影响因子：
14.2
作者：
Cosmi, Lorenzo;Maggi, Laura;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
32.4
作者：
Bernink, Jochem H.;Krabbendam, Lisette;Spits, Hergen
通讯作者：
Spits, Hergen