Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting.
Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting.
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24小时内脑内注射钆基造影剂的颅内分布：3D真实红外成像和MR指纹图评价。
DOI：
10.2463/mrms.mp.2020-0030
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发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Sone M
中科院分区：
文献类型：
--
作者：
Naganawa S;Ito R;Kato Y;Kawai H;Taoka T;Yoshida T;Maruyama K;Murata K;Körzdörfer G;Pfeuffer J;Nittka M;Sone M
为了评价静脉注射单剂量钆基造影剂（IV-SD-GBCA）后检测轻微造影剂效应的可行性，使用3D-真实IR成像和MR指纹（MRF）检查了不同液体空间和脑实质中GBCA分布的时间过程长达24 h。在给药前和IV-SD-GBCA后10 min、4 h和24 h对24例疑似内淋巴积水的患者进行扫描。获得内耳道水平的3D真实IR图像和MRF。测量桥小脑角池（CPA）、侧裂（Syl）、侧脑室（LV）和耳蜗外淋巴液（CPL）中脑脊液（CSF）的三维实时红外图像上的信号强度。用磁共振波谱仪测量小脑灰质（GM）和白色质（WM）的T1和T2值。使用方差分析比较不同时间点的每个平均值。3D-real IR图像上CSF各区域的信号强度在4 h达到峰值，到24 h显著降低（P < 0.05）。所有患者的CPA和Syl在4 h时均出现最大信号强度。CPL平均信号强度在4 h达到峰值，24 h显著下降（P < 0.05）。除两名患者外，所有患者均在4 h时出现最大信号强度。关于小脑WM和GM的T1值，IV-GBCA后10分钟的T1值与对比扫描前相比显着降低，但在其他时间点没有观察到显着差异。在任何时间点，灰色或白色物质的T2均无显著变化。IV-SD-GBCA后GBCA的时间过程可以通过CSF空间中的3D-真实IR成像和通过MRF在脑中进行评估。
To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF). Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T1 and T2 values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance. The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (P < 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (P < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T1 value in the cerebellar WM and GM, the T1 value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T2 in the gray or white matter at any of the time points. Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF.
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影响因子：
3.3
作者：
Chung, Sohae;Kim, Daniel;Breton, Elodie;Axel, Leon
通讯作者：
Axel, Leon
DOI：
10.2463/mrms.mp.2019-0016
发表时间：
2020-08-03
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Kato Y;Ichikawa K;Okudaira K;Taoka T;Kawaguchi H;Murata K;Maruyama K;Koerzdoerfer G;Pfeuffer J;Nittka M;Naganawa S
通讯作者：
Naganawa S
DOI：
10.2463/mrms.bc.2017-0158
发表时间：
2019-01-10
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa S;Kawai H;Taoka T;Sone M
通讯作者：
Sone M
影响因子：
3.5
作者：
Freeze, W. M.;Schnerr, R. S.;Backes, W. H.
通讯作者：
Backes, W. H.
影响因子：
3
作者：
Naganawa, Shinji;Suzuki, Kojiro;Sakurai, Yasuo
通讯作者：
Sakurai, Yasuo