Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria--an epidemiological investigation.
Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria--an epidemiological investigation.
复制标题
原发性肝癌的病因学，特别是酒精、有机溶剂和急性间歇性卟啉症——流行病学调查。
作者：
L. Hardell;N. Bengtsson;U. Jonsson;S. Eriksson;L. Larsson
本文对102例男性原发性肝癌（PLC）的环境因素进行了病例对照研究，其中肝细胞癌（HCC）83例，肝内胆管细胞癌（CC）15例，血管肉瘤3例，未特指肉瘤1例。在每种情况下使用两个匹配的对照。1例血管肉瘤患者暴露于聚氯乙烯。未指明软组织肉瘤的病例暴露于苯氧酸。酗酒者患肝癌的风险增加4倍，经常饮酒的风险增加3倍。暴露于有机溶剂使HCC的风险增加2倍。没有观察到接触各种其他化学品的病例风险增加。3例HCC患者既往诊断为急性卟啉病（派），而对照组无。6例HCC患者既往诊断为急性卟啉病（派），而对照组无。6例PLC合并迟发性皮肤多发性卟啉症（PCT），其中4例与酒精中毒有关，1例与血色病有关。
Some environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma (HCC), 15 cases of intrahepatic cholangiocellular carcinoma (CC), 3 cases of haemangiosarcoma and 1 case of unspecified sarcoma in the liver--102 cases in total. Two matched controls were used in each case. One case with haemangiosarcoma was exposed to polyvinyl chloride. The case with unspecified soft-tissue sarcoma was exposed to phenoxy acids. A 4-fold increase in the risk of HCC was seen in alcoholics, and regular drinking gave a 3-fold increase in the risk. Exposure to organic solvents gave a 2-fold increase in the risk of HCC. No increased risk was observed for cases exposed to various other chemicals. Three cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases with PLC had polyphyria cutanea tarda (PCT) which in 4 cases was related to alcoholism and in one case to haemochromatosis.
影响因子：
11.2
作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson
通讯作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson