Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy.
Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy.
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DOI：
10.1093/jjco/hyu221
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发表时间：
2015-05
影响因子：
2.4
通讯作者：
Yamashita Y
中科院分区：
文献类型：
--
作者：
Yamashita Y
直到最近，卵巢透明细胞癌被认为是其独特的形态和不利的患者结果，主要是由于肿瘤化疗耐药性。近年来，卵巢透明细胞癌的特异性分子特征，如PI3CA突变、ARID1a突变和MET扩增已被阐明。此外，子宫内膜异位症与肿瘤之间的关系也是近年来研究的焦点。这篇综述的目的是讨论分子变化的特异性和重要性，以及直到今天还没有解决的各种有趣的问题。最后，未来的方面，包括新疗法的发展希望，进行了讨论。
Until recently, ovarian clear cell carcinoma was recognized by its unique morphology and unfavorable patient outcome primarily due to tumor chemoresistance. Recently, specific molecular characteristics of ovarian clear cell carcinoma, such as PI3CA mutation, ARID1a mutation and MET amplification, have been elucidated. In addition, an association between endometriosis and the tumor has also been a focus of research in recent years. The aim of this review is to discuss the specificity and importance of molecular changes and various intriguing points that are not solved until today. Finally, future aspects, including hopes for the development of novel therapies, are discussed.
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