αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target.
αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target.
复制标题
DOI：
10.1016/j.pharmthera.2016.01.012
复制
发表时间：
2016-04
影响因子：
13.5
通讯作者：
Cryns, Vincent L.
中科院分区：
文献类型：
--
作者：
Malin, Dmitry;Petrovic, Vladimir;Strekalova, Elena;Sharma, Bhawna;Cryns, Vincent L.
α B-晶状体蛋白是一种广泛表达的小分子热休克蛋白家族成员，通过其双重功能保护细胞免受应激，作为分子伴侣以保持蛋白质稳态，并作为细胞死亡拮抗剂，负性调节保守的凋亡细胞死亡机制的组分。α B-晶状体蛋白的表达失调发生在广泛的实体瘤中，并与肿瘤进展和不良临床结局相关。本文就癌基因、氧化应激、基质分离等肿瘤微环境应激因子对α B晶体蛋白表达的调控机制进行综述。我们还将审查越来越多的证据，指出α B-晶体蛋白在多步转移级联反应中的重要作用，肿瘤细胞通过绕过细胞迁移和存活的众多障碍，在远处器官中定植。最后，我们将评估治疗靶向α B-晶状体蛋白和/或相互作用蛋白的新兴策略，以选择性激活细胞凋亡和/或破坏转移级联反应，以改善转移性疾病患者的结局。
αB-crystallin is a widely expressed member of the small heat shock protein family that protects cells from stress by its dual function as a molecular chaperone to preserve proteostasis and as a cell death antagonist that negatively regulates components of the conserved apoptotic cell death machinery. Deregulated expression of αB-crystallin occurs in a broad array of solid tumors and has been linked to tumor progression and poor clinical outcomes. This review will focus on new insights into the molecular mechanisms by which oncogenes, oxidative stress, matrix detachment and other tumor microenvironmental stressors deregulate αB-crystallin expression. We will also review accumulating evidence pointing to an essential role for αB-crystallin in the multi-step metastatic cascade whereby tumor cells colonize distant organs by circumventing a multitude of barriers to cell migration and survival. Finally, we will evaluate emerging strategies to therapeutically target αB-crystallin and/or interacting proteins to selectively activate apoptosis and/or derail the metastatic cascade in an effort to improve outcomes for patients with metastatic disease.
登录
查看更多内容
影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
DOI：
10.1016/j.jss.2014.03.042
发表时间：
2014-08
期刊：
The Journal of surgical research
影响因子：
--
作者：
Davidov T;Nagar M;Kierson M;Chekmareva M;Chen C;Lu SE;Lin Y;Chernyavsky V;Potdevin L;Arumugam D;Barnard N;Trooskin S
通讯作者：
Trooskin S
影响因子：
3.2
作者：
Acunzo, Julie;Andrieu, Claudia;Rocchi, Palma
通讯作者：
Rocchi, Palma
影响因子：
64.5
作者：
Dai, Chengkai;Whitesell, Luke;Lindquist, Susan
通讯作者：
Lindquist, Susan
DOI：
10.1016/j.bbrc.2003.09.186
发表时间：
2003-11-07
影响因子：
3.1
作者：
Aki, T;Yoshida, K;Mizukami, Y
通讯作者：
Mizukami, Y