Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale.
Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale.
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DOI：
10.1159/000514519
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Albert M
中科院分区：
文献类型：
--
作者：
Pantelyat A;Higginbotham L;Rosenthal L;Lanham D;Nesspor V;AlSalihi M;Bang J;Wang J;Albert M
在临床试验中使用患者报告的结果作为终点的兴趣越来越大，例如进行性核上性麻痹生活质量量表（PSP-QoL）。然而，该工具尚未得到广泛验证，其与经验证的运动量表的相关性尚未得到探讨。为了评价使用PSP-QoL作为结局的潜在效用，重要的是检查其与用于评价神经学参数的标准量表（如PSP评定量表）的关系。从60例临床诊断的PSP患者中收集PSP-QoL和PSP评定量表评分，包括Richardson综合征PSP（PSP-RS，n=43）和非RS PSP变体（n=17）患者。调整年龄、性别和病程的线性回归分析用于评估两种工具的总分和分量表评分之间的横截面关系。在60例PSP患者中，总PSP生活质量与PSP评定量表评分之间存在显著相关性。每个仪器的物理和精神状态分量表也表现出显着的相关性。PSP亚型之间的比较表明，恶化的PSP生活质量总和物理子量表评分与恶化的PSP评定量表步态子量表评分的相关性更强的非RS PSP变体比PSP-RS。PSP生活质量和PSP评定量表的总分与许多子量表评分之间存在显著相关性。此外，对于PSP-RS和非RS变体，这些测量之间的关系可能不同。这些结果表明，PSP生活质量可能是有用的，在临床试验中作为一个病人报告的结果措施。有必要利用PSP-QoL进行大型前瞻性多中心研究，以检查其与疾病进展和PSP评定量表变化的关系。
There is growing interest in using patient-reported outcomes as endpoints in clinical trials, such as the progressive supranuclear palsy quality of life scale (PSP-QoL). However, this tool has not been widely validated and its correlation with validated motor scales has not been explored. To evaluate the potential utility of using PSP-QoL as an outcome, it is important to examine its relationship with a standard scale used to evaluate neurologic parameters, such as the PSP Rating Scale. PSP-QoL and PSP Rating Scale scores were gathered from 60 clinically diagnosed PSP patients, including patients with Richardson’s Syndrome PSP (PSP-RS, n=43) and those with non-RS PSP variants (n=17). Linear regression analysis adjusted for age, sex, and disease duration was used to evaluate the cross-sectional relationship between the total and subscale scores of the two instruments. Among 60 PSP patients, there was a significant correlation between total PSP-QoL and PSP Rating Scale scores. The physical and mentation subscales of each instrument also demonstrated significant correlations. Comparisons among PSP subtypes indicated that worsening PSP-QoL Total and Physical subscale scores correlated with worsening PSP Rating Scale Gait subscale scores more strongly for the non-RS PSP variants than for PSP-RS. There is a significant association between the total scores and many of the subscale scores of the PSP-QoL and the PSP Rating Scale. Additionally, the relationship between these measures may differ for PSP-RS and non-RS variants. These findings suggest that the PSP-QoL may be useful in clinical trials as a patient-reported outcome measure. Large prospective multicenter studies utilizing the PSP-QoL are necessary to examine its relationship to disease evolution and changes in the PSP Rating Scale.
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影响因子：
9.9
作者：
Nath, U;Ben-Shlomo, Y;Burn, DJ
通讯作者：
Burn, DJ
影响因子：
3.7
作者：
SIDAK, Z
通讯作者：
SIDAK, Z
影响因子：
14.5
作者：
Williams, DR;de Silva, R;Lees, AJ
通讯作者：
Lees, AJ
影响因子：
3.5
作者：
Black, Betty S.;Johnston, Deirdre;Morrison, Ann;Rabins, Peter V.;Lyketsos, Constantine G.;Samus, Quincy M.
通讯作者：
Samus, Quincy M.
影响因子：
8.6
作者：
Respondek, Gesine;Roeber, Sigrun;Hoeglinger, Guenter U.
通讯作者：
Hoeglinger, Guenter U.