Evaluating the loudness of phantom auditory perception (tinnitus) in rats.
Evaluating the loudness of phantom auditory perception (tinnitus) in rats.
复制标题
评估大鼠幻觉听觉（耳鸣）的响度。
DOI：
10.3109/00206099409071881
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
J. Brennan
中科院分区：
文献类型：
--
作者：
P. Jastreboff;J. Brennan
用我们建立的评价耳鸣的行为范式，通过比较不同剂量水杨酸盐诱发的行为反应和不同强度的模拟耳鸣的连续参考音诱发的行为反应，对144只大鼠的水杨酸诱发耳鸣的响度进行了评价。组内对消光的抵抗力差异与水杨酸盐剂量呈线性相关，在中等强度时，也与参考音调有关。比较水杨酸盐和音调效应的回归方程，可以估计水杨酸盐引起的耳鸣的响度。这些结果扩展了耳鸣的动物模型，为幻听听觉的响度是通过可观察的行为来表达的，可以被评估，并可以检测到它的变化提供了证据。
Using our behavioral paradigm for evaluating tinnitus, the loudness of salicylate-induced tinnitus was evaluated in 144 rats by comparing their behavioral responses induced by different doses of salicylate to those induced by different intensities of a continuous reference tone mimicking tinnitus. Group differences in resistance to extinction were linearly related to salicylate dose and, at moderate intensities, to the reference tone as well. Comparison of regression equations for salicylate versus tone effects permitted estimation of the loudness of salicylate-induced tinnitus. These results extend the animal model of tinnitus and provide evidence that the loudness of phantom auditory perception is expressed through observable behavior, can be evaluated, and its changes detected.
色素沉着、麻醉、行为因素和水杨酸盐吸收。
DOI：
10.1001/archotol.1988.01860140084027
发表时间：
1988
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
--
作者：
Jastreboff,PJ;Issing,W;Brennan,JF;Sasaki,CT
通讯作者：
Sasaki,CT
影响因子：
1.9
作者：
JASTREBOFF, PJ;BRENNAN, JF;SASAKI, CT
通讯作者：
SASAKI, CT