The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus-maze test, but not in the social interaction test
The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus-maze test, but not in the social interaction test
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一氧化氮合成抑制剂 L-NAME 在大鼠高架十字迷宫测试中产生类似焦虑的作用，但在社交互动测试中则不然
DOI：
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发表时间：
1998
影响因子：
4.1
通讯作者：
S. Shafi
中科院分区：
文献类型：
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作者：
A. L. Vale;Simon Green;A. Montgomery;S. Shafi
本研究采用高架十字迷宫和社会互动实验两种焦虑动物模型，观察了一氧化氮合酶抑制剂N-硝基-L-精氨酸甲酯（L-NAME）的作用。在高架十字迷宫中，L-NAME（12.5-50 mg/kg）具有致焦虑样特征，如在开放臂上花费的时间、开放臂进入、开放臂进入的百分比和头部下垂的剂量依赖性减少所示，但对伸展注意姿势的数量没有显著影响。相反，L-NAME（12.5-50毫克/公斤）未能修改花费在社会交往的时间，但确实减少了垂直活动的措施。L-NAME在两个焦虑范式的差异影响进行了讨论。
The effects of the nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME) were investigated in two animal models of anxiety: the elevated plus-maze and the social interaction test. In the elevated plus- maze, L-NAME (12.5-50 mg/kg) had an anxiogenic-like profile as indicated by dose-dependent reductions in the time spent on the open arms, open arm entries, the percentage of open arm entries and head dips, but there was no significant effect on the number of stretch attend postures. In contrast, L-NAME (12.5-50 mg/kg) failed to modify time spent in social interaction but did reduce a measure of vertical activity The differential effects of L-NAME in the two anxiety paradigms are discussed.
DOI：
10.1016/0006-291x(91)90403-t
发表时间：
1991-05-15
影响因子：
3.1
作者：
DWYER, MA;BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH