Secretory phospholipase A2 enzymes as pharmacological targets for treatment of disease.
Secretory phospholipase A2 enzymes as pharmacological targets for treatment of disease.
复制标题
DOI：
10.1016/j.bcp.2014.05.022
复制
发表时间：
2014-08-15
影响因子：
5.8
通讯作者：
Cummings, Brian S.
中科院分区：
文献类型：
--
作者：
Quach, Nhat D.;Arnold, Robert D.;Cummings, Brian S.
关键词：
磷脂酶A2（PLA 2）优先在sn-2位裂解磷脂，释放游离脂肪酸和溶血磷脂。它们根据大小、位置、功能、底物特异性和钙需求分为六大类。这些类别包括分泌型PLA 2（sPLA 2）、胞质型PLA 2（cPLA 2）、Ca 2+非依赖型PLA 2（iPLA 2）、血小板活化因子乙酰水解酶（PAF-AH）、溶酶体型PLA 2（LyPLA 2）和脂肪特异性PLA 2（AdPLA 2）。据推测，PLA 2可以作为药理学靶标用于治疗多种疾病，包括心血管疾病、动脉粥样硬化、免疫疾病和癌症。特别强调sPLA 2亚型的抑制剂作为药理学部分，主要是由于这些酶在炎症事件期间被激活的事实，并且因为它们的表达在几种疾病中增加。本综述着重于了解sPLA 2亚型表达在疾病进展过程中是如何改变的，以及特异性靶向sPLA 2亚型的可能的治疗干预措施，包括使用基于纳米颗粒的策略的新方法。
Phospholipase A2 (PLA2) cleave phospholipids preferentially at the sn-2 position, liberating free fatty acids and lysophospholipids. They are classified into six main groups based on size, location, function, substrate specificity and calcium requirement. These classes include secretory PLA2 (sPLA2), cytosolic (cPLA2), Ca2+-independent (iPLA2), platelet activating factor acetylhydrolases (PAF-AH), lysosomal PLA2 (LyPLA2) and adipose specific PLA2 (AdPLA2). It is hypothesized that PLA2 can serve as pharmacological targets for the therapeutic treatment of several diseases, including cardiovascular diseases, atherosclerosis, immune disorders and cancer. Special emphasis has been placed on inhibitors of sPLA2 isoforms as pharmacological moieties, mostly due to the fact that these enzymes are activated during inflammatory events and because their expression is increased in several diseases. This review focuses on understanding how sPLA2 isoform expression is altered during disease progression and the possible therapeutic interventions to specifically target sPLA2 isoforms, including new approaches using nano-particulate-based strategies.
登录
查看更多内容
DOI：
10.1016/s1388-1981(00)00018-4
发表时间：
2000-04-12
影响因子：
4.8
作者：
Buckland, AG;Heeley, EL;Wilton, DC
通讯作者：
Wilton, DC
影响因子：
7.7
作者：
Augert, Arnaud;Payre, Christine;Bernard, David
通讯作者：
Bernard, David
影响因子：
5.2
作者：
Anderson, GG;Morrison, JFJ
通讯作者：
Morrison, JFJ
DOI：
10.1111/j.1432-1033.1994.tb18761.x
发表时间：
1994-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
DUA, R;CHO, W
通讯作者：
CHO, W
影响因子：
5.3
作者：
Gutierrez, Jaime;Brandan, Enrique
通讯作者：
Brandan, Enrique