Utility of diffusion-weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization.
Utility of diffusion-weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization.
复制标题
使用弥散加权成像评估经动脉化疗栓塞后肝细胞癌的生存能力。
DOI：
10.3892/ol.2014.2228
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发表时间：
2014-08
期刊：
影响因子：
2.9
通讯作者：
Xiao XS
中科院分区：
文献类型：
--
作者：
Yuan Z;Li WT;Ye XD;Peng WJ;Xiao XS
本研究的目的是评价弥散加权成像（DWI）是否可用于评估肝细胞癌（HCC）经动脉化疗栓塞（TACE）后的生存能力。共41例连续患者根据化疗栓塞方案进行治疗。在化疗栓塞后6 - 8周通过多探测器计算机断层扫描[或增强磁共振成像（MRI）]和DW-MRI在同一天进行随访。根据欧洲肝脏研究协会评估任何残留肿瘤的存在和肿瘤坏死的程度。记录治疗肿块的整个区域以及活体和坏死肿瘤组织的表观扩散系数（ADC）值。还计算相关系数以比较坏死百分比与ADC值。坏死和存活肿瘤组织的平均ADC值分别为2.22±0.31×10−3 mm 2/sec和1.42±0.25×10−3 mm 2/sec（Mann-Whitney U检验，P<0.001）。受试者工作特性分析结果显示，阈值ADC值为1.84×10−3 mm 2/sec，识别坏死肿瘤组织的灵敏度为92.3%，特异性为100%。病灶全面积ADC值与肿瘤坏死范围呈显著线性回归关系（r=0.58; P<0.001）。总之，DWI可用于评估TACE后HCC的生存能力。
The purpose of the present study was to evaluate whether diffusion-weighted imaging (DWI) can be used to assess hepatocellular carcinoma (HCC) viability following transarterial chemoembolization (TACE). A total of 41 consecutive patients were treated according to chemoembolization protocols. The follow-up was performed between six and eight weeks post-chemoembolization by multidetector computed tomography [or enhanced magnetic resonance imaging (MRI)] and DW-MRI on the same day. The presence of any residual tumor and the extent of tumor necrosis were evaluated according to the European Association for the Study of the Liver. The apparent diffusion coefficient (ADC) values of the entire area of the treated mass and the vital and necrotic tumor tissues were recorded. Correlation coefficients were also calculated to compare the percentage of necrosis with ADC values. The mean ADC values of the necrotic and vital tumor tissues were 2.22±0.31×10−3 mm2/sec and 1.42±0.25×10−3 mm2/sec, respectively (Mann-Whitney U test, P<0.001). The results from the receiver operating characteristic analysis showed that the threshold ADC value was 1.84×10−3 mm2/sec with 92.3% sensitivity and 100% specificity for identifying the necrotic tumor tissues. A significant linear regression correlation was identified between the ADC value of the entire area of the treated mass and the extent of tumor necrosis (r=0.58; P<0.001). In conclusion, DWI can be used to assess HCC viability following TACE.
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影响因子：
19.7
作者：
Sadowski, Elizabeth A.;Bennett, Lindsey K.;Djamali, Arjang
通讯作者：
Djamali, Arjang
影响因子：
19.7
作者：
Mürtz, P;Flacke, S;Schild, HH
通讯作者：
Schild, HH
DOI：
10.2214/ajr.04.1932
发表时间：
2006-10-01
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Lim, Hyo Soon;Jeong, Yong Yeon;Park, Jin Gyoon
通讯作者：
Park, Jin Gyoon
影响因子：
2.9
作者：
Kloeckner, Roman;Otto, Gerd;Pitton, Michael B.
通讯作者：
Pitton, Michael B.
影响因子：
5
作者：
Koh, Dow-Mu;Scurr, Erica;Husband, Janet E.
通讯作者：
Husband, Janet E.