Heterobifunctional PEG-grafted black phosphorus quantum dots: "Three-in-One" nano-platforms for mitochondria-targeted photothermal cancer therapy.
Heterobifunctional PEG-grafted black phosphorus quantum dots: "Three-in-One" nano-platforms for mitochondria-targeted photothermal cancer therapy.
复制标题
异双功能聚乙二醇接枝黑磷量子点：线粒体靶向光热癌症治疗的“三合一”纳米平台。
DOI：
10.1016/j.ajps.2020.09.001
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发表时间：
2021-03
影响因子：
10.2
通讯作者：
Deng W
中科院分区：
文献类型：
--
作者：
Qi J;Xiong Y;Cheng K;Huang Q;Cao J;He F;Mei L;Liu G;Deng W
黑磷(BP)纳米材料，特别是BP量子点(BPQds)具有优异的光热抗肿瘤效应、良好的生物相容性和生物降解性。然而，在提供真正的好处之前，有几个挑战需要克服，例如稳定性差、分散性差以及难以定制其他功能。在这里，设计了一种以线粒体为靶点的BP纳米平台，称为BPQD-PEG-TPP。在该纳米平台中，BPQD与异双官能团的聚乙二醇共价接枝，一端是能与BPQD反应形成共价键的芳基重氮基，另一端是线粒体靶向的三苯基膦(TPP)基团。除了具有优良的近红外光热性能外，BPQD-PEG-TPP还具有在生理条件下的稳定性和分散性大大增强，有效的线粒体靶向，并通过光热效应促进ROS的产生。体外和体内实验表明，作为线粒体靶向PTT，BPQD-PEG-TPP的光热细胞毒性明显优于BPQDS和BPQD-PEG。因此，这种通过聚合物接枝制备的三合一纳米平台具有良好的稳定性、分散性和可忽略的副作用，可能是一种很有前途的线粒体靶向光热治疗策略。由于黑磷量子点的稳定性和分散性较差，要提供真正的好处仍然是一个挑战。在这里，作者报道了一种基于BPQDS的三合一纳米平台，通过简单的异双功能聚乙二醇酯接枝，提高了稳定性、分散性和线粒体靶向性，用于光热治疗癌症。
Black phosphorus (BP) nano-materials, especially BP quantum dots (BPQDs), performs outstanding photothermal antitumor effects, excellent biocompatibility and biodegradability. However, there are several challenges to overcome before offering real benefits, such as poor stability, poor dispersibility as well as difficulty in tailoring other functions. Here, a “three-in-one” mitochondria-targeted BP nano-platform, called as BPQD-PEG-TPP, was designed. In this nano-platform, BPQDs were covalently grafted with a heterobifunctional PEG, in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine (TPP) group. In addition to its excellent near-infrared photothermal properties, BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions, efficient mitochondria targeting and promoted ROS production through a photothermal effect. Both in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted PTT. Thus this “three-in-one” nanoplatform fabricated through polymer grafting, with excellent stability, dispersibility and negligible side effects, might be a promising strategy for mitochondria-targeted photothermal cancer therapy. It is still a challenge for black phosphorus quantum dots (BPQDs) to offer real benefits because of their poor stability and dispersibility. Here, the authors report a BPQDs-based “three-in-one” nano-platform with enhanced stability, dispersibility and mitochondria targeting for photothermal cancer therapy through simple heterobifunctional PEG grafting.
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