Short-term change in growth of uterine leiomyoma: tumor growth spurts.
Short-term change in growth of uterine leiomyoma: tumor growth spurts.
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DOI：
10.1016/j.fertnstert.2010.05.011
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发表时间：
2011-01
影响因子：
6.7
通讯作者：
Peddada, Shyamal D.
中科院分区：
文献类型：
--
作者：
Baird, Donna Day;Garrett, Tiana A.;Laughlin, Shannon K.;Davis, Barbara;Semelka, Richard C.;Peddada, Shyamal D.
关键词：
描述子宫平滑肌瘤（肌瘤）生长的短期变化。前瞻性观察性研究大学研究中心绝经前子宫肌瘤妇女（n = 18名黑人和18名白人）通过医生网络和社区外展招募。不适用因在入组时、3个月、6个月和12个月时用磁共振成像（MRI）测量了101个肌瘤的体积，得到了三个时间间隔特异性生长率。生长突增定义为每3个月的间隔生长率≥ 30%，并且显著大于其他观察间隔。肌瘤生长的短期变化的总体测量被计算为三个间隔特异性生长速率的方差。在101个肌瘤中的37个中观察到生长突增，其患病率比归因于潜在测量误差的患病率高近10倍。来自相同女性的肌瘤没有相似的短期生长（p=0.27），女性特异性因素（年龄、种族/民族、产次、体重）或子宫中肌瘤的位置也不重要。然而，大肌瘤（直径>5 cm）的短期变化小于小肌瘤（p<0.001）。短的生长高峰在肌瘤中很常见，这表明肿瘤生物学可能会迅速改变。
To describe the short-term changes in growth of uterine leiomyomata (fibroids). Prospective observational study University Research Center Premenopausal women with fibroids (n = 18 blacks and 18 whites) recruited through a physician network and community outreach. Not applicable. The volumes of 101 fibroids were measured at enrollment, 3, 6, and 12 months with magnetic resonance imaging (MRI), resulting in three interval-specific growth rates. Growth spurts were defined by interval growth rates ≥ 30% per 3 months and substantially greater than during other intervals of observation. An overall measure of short-term change in fibroid growth was calculated as the variance of the three interval-specific growth rates. Growth spurts were observed in 37 of the 101 fibroids, a prevalence nearly 10 times higher than that attributable to potential measurement error. Fibroids from the same women did not have similar short-term growth (p=0.27), nor were woman-specific factors (age, race/ethnicity, parity, body mass) or the fibroid position in the uterus important. However, large fibroids (>5 cm diameter) had less short-term change than smaller fibroids (p<0.001). Short spurts of growth are common for fibroids, suggesting that tumor biology may change rapidly.
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影响因子：
7.2
作者：
Farquhar, CM;Steiner, CA
通讯作者：
Steiner, CA
影响因子：
6.7
作者：
Ichimura, T;Kawamura, N;Ogita, S
通讯作者：
Ogita, S
DOI：
10.1073/pnas.0808188105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Peddada, Shyamal D.;Laughlin, Shannon K.;Baird, Donna Day
通讯作者：
Baird, Donna Day
DOI：
10.1016/j.urolonc.2008.03.010
发表时间：
2008-09-01
影响因子：
2.7
作者：
Crispen, Paul L.;Wong, Yu-Ning;Uzzo, Robert G.
通讯作者：
Uzzo, Robert G.
影响因子：
3.5
作者：
Davis, Barbara J.;Haneke, Karen E.;Baird, Donna Day
通讯作者：
Baird, Donna Day