Building a collaborative cloud platform to accelerate heart, lung, blood, and sleep research.
Building a collaborative cloud platform to accelerate heart, lung, blood, and sleep research.
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DOI：
10.1093/jamia/ocad048
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发表时间：
2023-06-20
影响因子：
6.4
通讯作者：
Asare, Joe
中科院分区：
文献类型：
--
作者：
Ahalt, Stan;Avillach, Paul;Boyles, Rebecca;Bradford, Kira;Cox, Steven;Davis-Dusenbery, Brandi;Grossman, Robert L.;Krishnamurthy, Ashok;Manning, Alisa;Paten, Benedict;Philippakis, Anthony;Borecki, Ingrid;Chen, Shu Hui;Kaltman, Jon;Ladwa, Sweta;Schwartz, Chip;Thomson, Alastair;Davis, Sarah;Leaf, Alison;Lyons, Jessica;Sheets, Elizabeth;Bis, Joshua C.;Conomos, Matthew;Culotti, Alessandro;Desain, Thomas;Digiovanna, Jack;Domazet, Milan;Gogarten, Stephanie;Gutierrez-Sacristan, Alba;Harris, Tim;Heavner, Ben;Jain, Deepti;O'Connor, Brian;Osborn, Kevin;Pillion, Danielle;Pleiness, Jacob;Rice, Ken;Rupp, Garrett;Serret-Larmande, Arnaud;Smith, Albert;Stedman, Jason P.;Stilp, Adrienne;Barsanti, Teresa;Cheadle, John;Erdmann, Christopher;Farlow, Brandy;Gartland-Gray, Allie;Hayes, Julie;Hiles, Hannah;Kerr, Paul;Lenhardt, Chris;Madden, Tom;Mieczkowska, Joanna O.;Miller, Amanda;Patton, Patrick;Rathbun, Marcie;Suber, Stephanie;Asare, Joe
研究越来越依赖于询问大规模数据资源。NIH国家心脏、肺和血液研究所开发了NHLBI BioData CatalystR(BDC)，这是一个社区驱动的生态系统，包括BASK和临床科学家、统计学家和算法开发人员在内的研究人员在大型数据集上查找、访问、共享、存储和计算。该生态系统提供基于云的安全工作空间、用户身份验证和授权、搜索、工具和工作流程、应用程序以及新的创新功能，以满足社区需求，包括探索性数据分析、基因组和成像工具、可再生性工具，以及改进与其他NIH数据科学平台的互操作性。BDC提供对大规模数据集和计算资源的直接访问，这些数据集和计算资源支持心、肺、血液和睡眠状况的精准医学，利用单独开发和管理的平台，根据研究人员的需求、专业知识和背景最大限度地提高灵活性。通过NHLBI生物数据催化剂研究员计划，BDC促进了科学发现和技术进步。疾病预防控制中心还促进了对冠状病毒病-2019年(新冠肺炎)大流行的加速研究。
Research increasingly relies on interrogating large-scale data resources. The NIH National Heart, Lung, and Blood Institute developed the NHLBI BioData CatalystⓇ (BDC), a community-driven ecosystem where researchers, including bench and clinical scientists, statisticians, and algorithm developers, find, access, share, store, and compute on large-scale datasets. This ecosystem provides secure, cloud-based workspaces, user authentication and authorization, search, tools and workflows, applications, and new innovative features to address community needs, including exploratory data analysis, genomic and imaging tools, tools for reproducibility, and improved interoperability with other NIH data science platforms. BDC offers straightforward access to large-scale datasets and computational resources that support precision medicine for heart, lung, blood, and sleep conditions, leveraging separately developed and managed platforms to maximize flexibility based on researcher needs, expertise, and backgrounds. Through the NHLBI BioData Catalyst Fellows Program, BDC facilitates scientific discoveries and technological advances. BDC also facilitated accelerated research on the coronavirus disease-2019 (COVID-19) pandemic.
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影响因子：
120.7
作者：
Self, Wesley H.;Semler, Matthew W.;Brown, Samuel M.
通讯作者：
Brown, Samuel M.
DOI：
10.1093/jamia/ocaa068
发表时间：
2020-09-01
期刊：
Journal of the American Medical Informatics Association : JAMIA
影响因子：
--
作者：
Krissaane I;De Niz C;Gutiérrez-Sacristán A;Korodi G;Ede N;Kumar R;Lyons J;Manrai A;Patel C;Kohane I;Avillach P
通讯作者：
Avillach P
影响因子：
64.8
作者：
Taliun D;Harris DN;Kessler MD;Carlson J;Szpiech ZA;Torres R;Taliun SAG;Corvelo A;Gogarten SM;Kang HM;Pitsillides AN;LeFaive J;Lee SB;Tian X;Browning BL;Das S;Emde AK;Clarke WE;Loesch DP;Shetty AC;Blackwell TW;Smith AV;Wong Q;Liu X;Conomos MP;Bobo DM;Aguet F;Albert C;Alonso A;Ardlie KG;Arking DE;Aslibekyan S;Auer PL;Barnard J;Barr RG;Barwick L;Becker LC;Beer RL;Benjamin EJ;Bielak LF;Blangero J;Boehnke M;Bowden DW;Brody JA;Burchard EG;Cade BE;Casella JF;Chalazan B;Chasman DI;Chen YI;Cho MH;Choi SH;Chung MK;Clish CB;Correa A;Curran JE;Custer B;Darbar D;Daya M;de Andrade M;DeMeo DL;Dutcher SK;Ellinor PT;Emery LS;Eng C;Fatkin D;Fingerlin T;Forer L;Fornage M;Franceschini N;Fuchsberger C;Fullerton SM;Germer S;Gladwin MT;Gottlieb DJ;Guo X;Hall ME;He J;Heard-Costa NL;Heckbert SR;Irvin MR;Johnsen JM;Johnson AD;Kaplan R;Kardia SLR;Kelly T;Kelly S;Kenny EE;Kiel DP;Klemmer R;Konkle BA;Kooperberg C;Köttgen A;Lange LA;Lasky-Su J;Levy D;Lin X;Lin KH;Liu C;Loos RJF;Garman L;Gerszten R;Lubitz SA;Lunetta KL;Mak ACY;Manichaikul A;Manning AK;Mathias RA;McManus DD;McGarvey ST;Meigs JB;Meyers DA;Mikulla JL;Minear MA;Mitchell BD;Mohanty S;Montasser ME;Montgomery C;Morrison AC;Murabito JM;Natale A;Natarajan P;Nelson SC;North KE;O'Connell JR;Palmer ND;Pankratz N;Peloso GM;Peyser PA;Pleiness J;Post WS;Psaty BM;Rao DC;Redline S;Reiner AP;Roden D;Rotter JI;Ruczinski I;Sarnowski C;Schoenherr S;Schwartz DA;Seo JS;Seshadri S;Sheehan VA;Sheu WH;Shoemaker MB;Smith NL;Smith JA;Sotoodehnia N;Stilp AM;Tang W;Taylor KD;Telen M;Thornton TA;Tracy RP;Van Den Berg DJ;Vasan RS;Viaud-Martinez KA;Vrieze S;Weeks DE;Weir BS;Weiss ST;Weng LC;Willer CJ;Zhang Y;Zhao X;Arnett DK;Ashley-Koch AE;Barnes KC;Boerwinkle E;Gabriel S;Gibbs R;Rice KM;Rich SS;Silverman EK;Qasba P;Gan W;NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium;Papanicolaou GJ;Nickerson DA;Browning SR;Zody MC;Zöllner S;Wilson JG;Cupples LA;Laurie CC;Jaquish CE;Hernandez RD;O'Connor TD;Abecasis GR
通讯作者：
Abecasis GR
影响因子：
56.9
作者：
Siren, Jouni;Monlong, Jean;Chang, Xian;Novak, Adam M.;Eizenga, Jordan M.;Markello, Charles;Sibbesen, Jonas A.;Hickey, Glenn;Chang, Pi-Chuan;Carroll, Andrew;Gupta, Namrata;Gabriel, Stacey;Blackwell, Thomas W.;Ratan, Aakrosh;Taylor, Kent D.;Rich, Stephen S.;Rotter, Jerome, I;Haussler, David;Garrison, Erik;Paten, Benedict
通讯作者：
Paten, Benedict
影响因子：
3.2
作者：
St Martin, Andrew;Hebert, Kyle M.;Serret-Larmande, Arnaud;Jouhet, Vianney;Hughes, Emily;Stedman, Jason;DeSain, Thomas;Pillion, Danielle;Lyons, Jessica C.;Steinert, Patricia;Avillach, Paul;Eapen, Mary
通讯作者：
Eapen, Mary