Is serotonin uptake by peripheral tissues sensitive to hypoxia exposure?
Is serotonin uptake by peripheral tissues sensitive to hypoxia exposure?
复制标题
外周组织吸收血清素对缺氧敏感吗？
DOI：
10.1007/s10695-022-01083-3
复制
发表时间：
2022
影响因子：
2.9
通讯作者：
McDonald, M. Danielle
中科院分区：
文献类型：
--
作者：
Amador, Molly H.;McDonald, M. Danielle
在海湾蟾鱼（Opsanus beta）中，5-羟色胺（5-HT）转运蛋白（SERT）在心脏中高度表达，心脏和鳃都显示出SERT介导的从循环中摄取5-HT的能力。由于5-HT是鱼类的一种强效血管收缩剂，我们假设缺氧暴露可能会增加这些组织对5-HT的吸收，并增加5-HT的排泄，以防止阻碍气体交换的鳃血管收缩。对血液、胆汁和尿液的取样显示，慢性缺氧（1.83 ± 0.12 mg·L− 1 O2，持续24-26 h）的鱼，腹主动脉（心脏后）中的血浆5-HT比肝静脉（心脏前）中的血浆5-HT低41%，表明缺氧期间心脏5-HT摄取增强。胆汁中的5-HT浓度高于尿液中的5-HT浓度，但急性（1.31 ± 0.06 mg·L-1 O2，25 min）或慢性缺氧对这些液体中的5-HT浓度没有影响。在5-HT放射性示踪剂实验中，胆汁中示踪剂的存在减少缺氧暴露后，但令人惊讶的是，无论是急性或慢性缺氧引起的变化[3 H]5-HT摄取在心脏，鳃，或其他组织。考虑到低氧暴露对代谢率的可能影响，未来的研究应检查轻度低氧暴露对这些组织中5-HT摄取的影响以及5-HT降解的作用。
In the Gulf toadfish (Opsanus beta), the serotonin (5-HT) transporter (SERT) is highly expressed in the heart, and the heart and gill both demonstrate the capacity for SERT-mediated uptake of 5-HT from the circulation. Because 5-HT is a potent vasoconstrictor in fish, we hypothesized that hypoxia exposure may increase 5-HT uptake by these tissues—and increase excretion of 5-HT—to prevent branchial vasoconstriction that would hamper gas exchange. Spot sampling of blood, bile, and urine revealed that fish exposed to chronic hypoxia (1.83 ± 0.12 mg·L−1O2for 24–26 h) had 41% lower plasma 5-HT in the ventral aorta (immediately following the heart) than in the hepatic vein (immediately before the heart), suggesting enhanced cardiac 5-HT uptake during hypoxia. 5-HT concentrations in the bile were greater than those in the urine, but there were no effects of acute (1.31 ± 0.06 mg·L−1O2for 25 min) or chronic hypoxia on 5-HT levels in these fluids. In 5-HT radiotracer experiments, the presence of tracer in the bile decreased upon hypoxia exposure, but, surprisingly, neither acute nor chronic hypoxia-induced changes in [3H]5-HT uptake in the heart, gill, or other tissues. Given the likely impact of the hypoxia exposure on metabolic rate, future studies should examine the effects of a milder hypoxia exposure on 5-HT uptake into these tissues and the role of 5-HT degradation.
登录
查看更多内容
西布曲明代谢物 2 与其他单胺再摄取抑制剂的产热和抑制吞咽作用的比较。
影响因子：
5
作者：
Y. Liu;I. Connoley;J. Harrison;D. Heal;M. Stock
通讯作者：
M. Stock
影响因子：
5
作者：
Y. Liu;I. Connoley;D. Heal;M. Stock
通讯作者：
M. Stock
影响因子：
3
作者：
De Pedro, N;Pinillos, ML;Delgado, MJ
通讯作者：
Delgado, MJ
血清素对欧洲鳗（Anguilla anguilla）体内心脏循环系统的影响
DOI：
10.1007/bf00301176
发表时间：
2004
期刊：
Journal of Comparative Physiology B
影响因子：
--
作者：
J. Janvier;M. Peyraud;P. Soulier
通讯作者：
P. Soulier
DOI：
10.1038/oby.2002.72
发表时间：
2002-06-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Gutiérrez, A;Saracíbar, G;Portillo, MP
通讯作者：
Portillo, MP