Virtual treatment of basilar aneurysms using shape memory polymer foam.
Virtual treatment of basilar aneurysms using shape memory polymer foam.
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DOI：
10.1007/s10439-012-0719-9
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发表时间：
2013-04
影响因子：
3.8
通讯作者：
Maitland, D. J.
中科院分区：
文献类型：
--
作者：
Ortega, J. M.;Hartman, J.;Rodriguez, J. N.;Maitland, D. J.
对使用形状记忆聚合物（SMP）泡沫治疗的患者特定基底动脉瘤进行数值模拟。为了评估治疗后的血流动力学，采用两种建模方法。在第一，泡沫的几何形状是从微CT扫描和泡沫内的脉动血流模拟牛顿和非牛顿粘度模型。在第二种情况下，泡沫被表示为多孔介质连续体，其具有通过在与体内条件相当的流速范围内计算通过泡沫几何形状的压力梯度来确定的渗透性。虚拟血管造影和额外的后处理证明SMP泡沫显著降低了治疗动脉瘤内的血流速度，同时消除了治疗前动脉瘤内存在的高频速度波动。通过基于血液的停留时间和剪切速率的低保真度血栓形成模型获得整个SMP泡沫中血栓形成的初始位置的估计。牛顿粘度模型和多孔介质模型捕获了类似的定性趋势，尽管两者都在SMP泡沫内产生较小体积的血栓。
Numerical simulations are performed on patient-specific basilar aneurysms that are treated with shape memory polymer (SMP) foam. In order to assess the post-treatment hemodynamics, two modeling approaches are employed. In the first, the foam geometry is obtained from a micro-CT scan and the pulsatile blood flow within the foam is simulated for both Newtonian and non-Newtonian viscosity models. In the second, the foam is represented as a porous media continuum, which has permeability properties that are determined by computing the pressure gradient through the foam geometry over a range of flow speeds comparable to those of in vivo conditions. Virtual angiography and additional post-processing demonstrate that the SMP foam significantly reduces the blood flow speed within the treated aneurysms, while eliminating the high-frequency velocity fluctuations that are present within the pre-treatment aneurysms. An estimation of the initial locations of thrombus formation throughout the SMP foam is obtained by means of a low fidelity thrombosis model that is based upon the residence time and shear rate of blood. The Newtonian viscosity model and the porous media model capture similar qualitative trends, though both yield a smaller volume of thrombus within the SMP foam.
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DOI：
10.1097/00004647-200112000-00011
发表时间：
2001-12-01
影响因子：
6.3
作者：
Groden, C;Laudan, J;Zeumer, H
通讯作者：
Zeumer, H
影响因子：
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作者：
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DOI：
10.1115/1.3148470
发表时间：
2009-09-01
影响因子：
1.7
作者：
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通讯作者：
Rossmann, Jenn Stroud
影响因子：
3.8
作者：
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DOI：
10.1016/j.cma.2007.06.030
发表时间：
2008-01-01
影响因子：
7.2
作者：
Fogelson, Aaron L.;Guy, Robert D.
通讯作者：
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