Low-intensity vibration improves angiogenesis and wound healing in diabetic mice.
Low-intensity vibration improves angiogenesis and wound healing in diabetic mice.
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DOI：
10.1371/journal.pone.0091355
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Koh TJ
中科院分区：
文献类型：
--
作者：
Weinheimer-Haus EM;Judex S;Ennis WJ;Koh TJ
Chronic wounds represent a significant health problem, especially in diabetic patients. In the current study, we investigated a novel therapeutic approach to wound healing – whole body low-intensity vibration (LIV). LIV is anabolic for bone, by stimulating the release of growth factors, and modulating stem cell proliferation and differentiation. We hypothesized that LIV improves the delayed wound healing in diabetic mice by promoting a pro-healing wound environment. Diabetic db/db mice received excisional cutaneous wounds and were subjected to LIV (0.4 g at 45 Hz) for 30 min/d or a non-vibrated sham treatment (controls). Wound tissue was collected at 7 and 15 d post-wounding and wound healing, angiogenesis, growth factor levels and wound cell phenotypes were assessed. LIV increased angiogenesis and granulation tissue formation at day 7, and accelerated wound closure and re-epithelialization over days 7 and 15. LIV also reduced neutrophil accumulation and increased macrophage accumulation. In addition, LIV increased expression of pro-healing growth factors and chemokines (insulin-like growth factor-1, vascular endothelial growth factor and monocyte chemotactic protein-1) in wounds. Despite no evidence of a change in the phenotype of CD11b+ macrophages in wounds, LIV resulted in trends towards a less inflammatory phenotype in the CD11b− cells. Our findings indicate that LIV may exert beneficial effects on wound healing by enhancing angiogenesis and granulation tissue formation, and these changes are associated with increases in pro-angiogenic growth factors.
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DOI：
10.1177/1740774510371014
发表时间：
2010-08
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Kiel DP;Hannan MT;Barton BA;Bouxsein ML;Lang TF;Brown KM;Shane E;Magaziner J;Zimmerman S;Rubin CT
通讯作者：
Rubin CT
影响因子：
2.8
作者：
Lau, Esther;Lee, W. David;Li, Jason;Xiao, Andrew;Davies, John E.;Wu, Qianhong;Wang, Liyun;You, Lidan
通讯作者：
You, Lidan
影响因子：
8.8
作者：
Adams, JA;Mangino, MJ;Sackner, MA
通讯作者：
Sackner, MA
影响因子：
27.4
作者：
Hui, W;Rowan, AD;Cawston, T
通讯作者：
Cawston, T
影响因子：
4.7
作者：
Ennis, William J.;Meneses, Patricio;Borhani, Martin
通讯作者：
Borhani, Martin