Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.
Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.
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DOI：
10.3389/fendo.2017.00261
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发表时间：
2017
影响因子：
5.2
通讯作者：
Commisso C
中科院分区：
文献类型：
--
作者：
Recouvreux MV;Commisso C
癌基因突变，如RAS突变，不仅促进了增殖，而且还促进了代谢适应，赋予癌细胞在恶劣的肿瘤微环境中维持细胞生长的能力。这些适应可能代表了代谢的脆弱性，可以被利用来开发新的、更有效的癌症疗法。巨噬细胞吞噬是一种进化上保守的内吞途径，允许细胞外液通过大的内吞小泡内化，称为大胞饮小体。最近，在RAS驱动的癌细胞中，巨噬细胞吞噬被确定为一种营养清除途径。巨噬细胞对细胞外蛋白质的摄取，以及它们在内溶酶体内的进一步降解，为癌细胞代谢和肿瘤生长提供了亟需的氨基酸。在这里，我们回顾了控制巨噬细胞吞噬过程的分子机制，并讨论了最近的工作，这些工作为巨噬细胞吞噬作为癌细胞营养供应途径的重要作用提供了证据。
Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to develop novel and more efficient cancer therapies. Macropinocytosis is an evolutionarily conserved endocytic pathway that permits the internalization of extracellular fluid via large endocytic vesicles known as macropinosomes. Recently, macropinocytosis has been determined to function as a nutrient-scavenging pathway in Ras-driven cancer cells. Macropinocytic uptake of extracellular proteins, and their further degradation within endolysosomes, provides the much-needed amino acids that fuel cancer cell metabolism and tumor growth. Here, we review the molecular mechanisms that govern the process of macropinocytosis, as well as discuss recent work that provides evidence of the important role of macropinocytosis as a nutrient supply pathway in cancer cells.
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影响因子：
14.8
作者：
通讯作者：
--
影响因子：
82.9
作者：
Davidson SM;Jonas O;Keibler MA;Hou HW;Luengo A;Mayers JR;Wyckoff J;Del Rosario AM;Whitman M;Chin CR;Condon KJ;Lammers A;Kellersberger KA;Stall BK;Stephanopoulos G;Bar-Sagi D;Han J;Rabinowitz JD;Cima MJ;Langer R;Vander Heiden MG
通讯作者：
Vander Heiden MG
影响因子：
4.8
作者：
Cotter, Kristina;Capecci, Joseph;Forgac, Michael
通讯作者：
Forgac, Michael
DOI：
10.1073/pnas.1307237110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Kamphorst, Jurre J.;Cross, Justin R.;Rabinowitz, Joshua D.
通讯作者：
Rabinowitz, Joshua D.
肿瘤微环境产生的酸度驱动局部侵袭。
影响因子：
11.2
作者：
Estrella V;Chen T;Lloyd M;Wojtkowiak J;Cornnell HH;Ibrahim-Hashim A;Bailey K;Balagurunathan Y;Rothberg JM;Sloane BF;Johnson J;Gatenby RA;Gillies RJ
通讯作者：
Gillies RJ